Effects of prenatal gamma-irradiation on postnatal astrogliogenesis in the hippocampal formation of rat

1999
journal article
report
9
dc.abstract.otherFemale Wistar rats were exposed to a single 1.0 Cy dose of gamma radiation on gestational days 13, 15, 17 or 19 (E13, E15, E17 and E19, respectively). Their 8- and 16-day old male offsprings were injected with H-3-thymidine and sacrificed 4 h after the injection. Brain sections were immunostained for S100 beta protein and subjected to autoradiography. Thereafter, the dorsal parr of the hippocampal formation was examined microscopically and numbers and locations of proliferating astrocytes were recorded. Following prenatal irradiation, the intensity of astrocyte proliferation was considerably reduced, especially in the region of dentate gyrus. The reduction showed regular trend of changes being much stronger in brains irradiated on E19 than in those irradiated on E13. The changes, therefore, were related to the stage of brain development at which the irradiation was performed. A possible role of neuronal regulatory influence on the postnatal development of glial cells was discussed.pl
dc.affiliationWydział Biologii i Nauk o Ziemi : Instytut Zoologiipl
dc.contributor.authorJaneczko, Krzysztof - 128444 pl
dc.contributor.authorSetkowicz-Janeczko, Zuzanna - 131836 pl
dc.contributor.authorFrączek, Mariapl
dc.contributor.authorKochowska, Joannapl
dc.date.accessioned2016-09-28T10:29:29Z
dc.date.available2016-09-28T10:29:29Z
dc.date.issued1999pl
dc.description.additionalZuzanna Setkowicz-Janeczko podpisana: Zuzanna Setkowiczpl
dc.description.number2pl
dc.description.physical628-632pl
dc.description.volume816pl
dc.identifier.doi10.1016/S0006-8993(98)01247-5pl
dc.identifier.eissn1872-6240pl
dc.identifier.issn0006-8993pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/30914
dc.languageengpl
dc.language.containerengpl
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.licencebez licencji
dc.rights.uri*
dc.subtypeReportpl
dc.titleEffects of prenatal gamma-irradiation on postnatal astrogliogenesis in the hippocampal formation of ratpl
dc.title.journalBrain Researchpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.otherpl
Female Wistar rats were exposed to a single 1.0 Cy dose of gamma radiation on gestational days 13, 15, 17 or 19 (E13, E15, E17 and E19, respectively). Their 8- and 16-day old male offsprings were injected with H-3-thymidine and sacrificed 4 h after the injection. Brain sections were immunostained for S100 beta protein and subjected to autoradiography. Thereafter, the dorsal parr of the hippocampal formation was examined microscopically and numbers and locations of proliferating astrocytes were recorded. Following prenatal irradiation, the intensity of astrocyte proliferation was considerably reduced, especially in the region of dentate gyrus. The reduction showed regular trend of changes being much stronger in brains irradiated on E19 than in those irradiated on E13. The changes, therefore, were related to the stage of brain development at which the irradiation was performed. A possible role of neuronal regulatory influence on the postnatal development of glial cells was discussed.
dc.affiliationpl
Wydział Biologii i Nauk o Ziemi : Instytut Zoologii
dc.contributor.authorpl
Janeczko, Krzysztof - 128444
dc.contributor.authorpl
Setkowicz-Janeczko, Zuzanna - 131836
dc.contributor.authorpl
Frączek, Maria
dc.contributor.authorpl
Kochowska, Joanna
dc.date.accessioned
2016-09-28T10:29:29Z
dc.date.available
2016-09-28T10:29:29Z
dc.date.issuedpl
1999
dc.description.additionalpl
Zuzanna Setkowicz-Janeczko podpisana: Zuzanna Setkowicz
dc.description.numberpl
2
dc.description.physicalpl
628-632
dc.description.volumepl
816
dc.identifier.doipl
10.1016/S0006-8993(98)01247-5
dc.identifier.eissnpl
1872-6240
dc.identifier.issnpl
0006-8993
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/30914
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Dodaję tylko opis bibliograficzny
dc.rights.licence
bez licencji
dc.rights.uri*
dc.subtypepl
Report
dc.titlepl
Effects of prenatal gamma-irradiation on postnatal astrogliogenesis in the hippocampal formation of rat
dc.title.journalpl
Brain Research
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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