An inhibitory effect of interferon gamma on the injury-induced astrocyte proliferation in the postmitotic rat brain

1997
journal article
other documents
3
cris.lastimport.wos2024-04-09T19:13:51Z
dc.abstract.otherInfluence of interferon gamma (IFN gamma) on astrocytes proliferating in response to unilateral injury of the cerebral hemisphere was investigated in 30-day-old rats. The brain injury was followed by an immediate injection of IFN gamma into the lesion cavity. On 1st or 2nd day following injury the animals were injected with [H-3]thymidine and killed 4 h after the injection. The proliferating astrocytes were visualised by combination of immunocytochemical staining for glial fibrillary acidic protein (GFAP) and autoradiography. Thereafter, numbers of GFAP-immunopositive and autoradiographically-labeled astrocytes located within the region of injury were counted. On the day 1 after injury no effect of lFN gamma administration was seen. However, on day 2 the average 43% reduction of the number of proliferating astrocytes was recorded. The reduction showed no dose-dependent changes. This in vivo evidence of IFN gamma-induced suppression of astrocyte proliferation was considered in relation to other determinants of astrocyte reactivity existing in the injured brain.pl
dc.affiliationWydział Biologii i Nauk o Ziemi : Instytut Zoologiipl
dc.contributor.authorPawliński, Rafałpl
dc.contributor.authorJaneczko, Krzysztof - 128444 pl
dc.date.accessioned2016-09-28T09:50:25Z
dc.date.available2016-09-28T09:50:25Z
dc.date.issued1997pl
dc.description.number1-2pl
dc.description.physical231-234pl
dc.description.volume773pl
dc.identifier.doi10.1016/S0006-8993(97)01024-Xpl
dc.identifier.eissn1872-6240pl
dc.identifier.issn0006-8993pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/30905
dc.languageengpl
dc.language.containerengpl
dc.rights.licencebez licencji
dc.subtypeOtherDocumentspl
dc.titleAn inhibitory effect of interferon gamma on the injury-induced astrocyte proliferation in the postmitotic rat brainpl
dc.title.journalBrain Researchpl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T19:13:51Z
dc.abstract.otherpl
Influence of interferon gamma (IFN gamma) on astrocytes proliferating in response to unilateral injury of the cerebral hemisphere was investigated in 30-day-old rats. The brain injury was followed by an immediate injection of IFN gamma into the lesion cavity. On 1st or 2nd day following injury the animals were injected with [H-3]thymidine and killed 4 h after the injection. The proliferating astrocytes were visualised by combination of immunocytochemical staining for glial fibrillary acidic protein (GFAP) and autoradiography. Thereafter, numbers of GFAP-immunopositive and autoradiographically-labeled astrocytes located within the region of injury were counted. On the day 1 after injury no effect of lFN gamma administration was seen. However, on day 2 the average 43% reduction of the number of proliferating astrocytes was recorded. The reduction showed no dose-dependent changes. This in vivo evidence of IFN gamma-induced suppression of astrocyte proliferation was considered in relation to other determinants of astrocyte reactivity existing in the injured brain.
dc.affiliationpl
Wydział Biologii i Nauk o Ziemi : Instytut Zoologii
dc.contributor.authorpl
Pawliński, Rafał
dc.contributor.authorpl
Janeczko, Krzysztof - 128444
dc.date.accessioned
2016-09-28T09:50:25Z
dc.date.available
2016-09-28T09:50:25Z
dc.date.issuedpl
1997
dc.description.numberpl
1-2
dc.description.physicalpl
231-234
dc.description.volumepl
773
dc.identifier.doipl
10.1016/S0006-8993(97)01024-X
dc.identifier.eissnpl
1872-6240
dc.identifier.issnpl
0006-8993
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/30905
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights.licence
bez licencji
dc.subtypepl
OtherDocuments
dc.titlepl
An inhibitory effect of interferon gamma on the injury-induced astrocyte proliferation in the postmitotic rat brain
dc.title.journalpl
Brain Research
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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