Neuroprotective action of FK-506 (tacrolimus) after seizures induced with pilocarpine : quantitative and topographic elemental analysis of brain tissue

2010
journal article
article
28
cris.lastimport.wos2024-04-10T02:17:38Z
dc.abstract.otherIn the present work, X-ray fluorescence microscopy with a synchrotron Source for the exciting radiation was applied for topographic and quantitative elemental analysis of rat brain tissue in pilocarpine-induced epilepsy and neuroprotection with FK-506. The mass per unit area of the elements P, S, Cl, K, Ca, Fe, Cu, Zn, Se, Br, and Rb was determined in four fields of the hippocampal formation (sectors I and 3 of Ammon's horn-CA1, CA3; dentate gyrus; hilus of dentate gyrus) and the parietal cortex. The results obtained for epileptic rats treated with FK-506 (SNF) were compared with data obtained previously for epileptic rats (SNS) and a control group. Many statistically significant differences in elemental composition were observed between the SNF and SNS groups. Higher mass per unit area of P was noticed in CA1 and CA3 regions of the hippocampus of SNF rats in comparison with SNS rats. A similar relation was observed for K in all five brain areas analyzed. Also, Fe in CA3 and dentate gyrus, CU in the parietal cortex, and Zn in CA3 and in the cortex were present at a higher level in the SNF group in comparison with the SNS group. The findings obtained in the present study suggest that the neuroprotective action of FK-506 in epileptic rat brain may involve not only the inhibition of calcineurin but also blockade of the K(+) channels.pl
dc.affiliationWydział Biologii i Nauk o Ziemi : Instytut Zoologiipl
dc.contributor.authorChwiej, Joannapl
dc.contributor.authorJaneczko, Krzysztof - 128444 pl
dc.contributor.authorMarciszko, Mariannapl
dc.contributor.authorCzyżycki, Mateuszpl
dc.contributor.authorRickers, Karenpl
dc.contributor.authorSetkowicz-Janeczko, Zuzanna - 131836 pl
dc.date.accessioned2016-09-27T13:32:12Z
dc.date.available2016-09-27T13:32:12Z
dc.date.issued2010pl
dc.description.additionalZuzanna Setkowicz-Janeczko podpisana: Zuzanna Setkowiczpl
dc.description.number2pl
dc.description.physical283-289pl
dc.description.volume15pl
dc.identifier.doi10.1007/s00775-009-0597-2pl
dc.identifier.eissn1432-1327pl
dc.identifier.issn0949-8257pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/30852
dc.languageengpl
dc.language.containerengpl
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.licencebez licencji
dc.rights.uri*
dc.subtypeArticlepl
dc.titleNeuroprotective action of FK-506 (tacrolimus) after seizures induced with pilocarpine : quantitative and topographic elemental analysis of brain tissuepl
dc.title.journalJBIC. Journal of Biological Inorganic Chemistrypl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-10T02:17:38Z
dc.abstract.otherpl
In the present work, X-ray fluorescence microscopy with a synchrotron Source for the exciting radiation was applied for topographic and quantitative elemental analysis of rat brain tissue in pilocarpine-induced epilepsy and neuroprotection with FK-506. The mass per unit area of the elements P, S, Cl, K, Ca, Fe, Cu, Zn, Se, Br, and Rb was determined in four fields of the hippocampal formation (sectors I and 3 of Ammon's horn-CA1, CA3; dentate gyrus; hilus of dentate gyrus) and the parietal cortex. The results obtained for epileptic rats treated with FK-506 (SNF) were compared with data obtained previously for epileptic rats (SNS) and a control group. Many statistically significant differences in elemental composition were observed between the SNF and SNS groups. Higher mass per unit area of P was noticed in CA1 and CA3 regions of the hippocampus of SNF rats in comparison with SNS rats. A similar relation was observed for K in all five brain areas analyzed. Also, Fe in CA3 and dentate gyrus, CU in the parietal cortex, and Zn in CA3 and in the cortex were present at a higher level in the SNF group in comparison with the SNS group. The findings obtained in the present study suggest that the neuroprotective action of FK-506 in epileptic rat brain may involve not only the inhibition of calcineurin but also blockade of the K(+) channels.
dc.affiliationpl
Wydział Biologii i Nauk o Ziemi : Instytut Zoologii
dc.contributor.authorpl
Chwiej, Joanna
dc.contributor.authorpl
Janeczko, Krzysztof - 128444
dc.contributor.authorpl
Marciszko, Marianna
dc.contributor.authorpl
Czyżycki, Mateusz
dc.contributor.authorpl
Rickers, Karen
dc.contributor.authorpl
Setkowicz-Janeczko, Zuzanna - 131836
dc.date.accessioned
2016-09-27T13:32:12Z
dc.date.available
2016-09-27T13:32:12Z
dc.date.issuedpl
2010
dc.description.additionalpl
Zuzanna Setkowicz-Janeczko podpisana: Zuzanna Setkowicz
dc.description.numberpl
2
dc.description.physicalpl
283-289
dc.description.volumepl
15
dc.identifier.doipl
10.1007/s00775-009-0597-2
dc.identifier.eissnpl
1432-1327
dc.identifier.issnpl
0949-8257
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/30852
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Dodaję tylko opis bibliograficzny
dc.rights.licence
bez licencji
dc.rights.uri*
dc.subtypepl
Article
dc.titlepl
Neuroprotective action of FK-506 (tacrolimus) after seizures induced with pilocarpine : quantitative and topographic elemental analysis of brain tissue
dc.title.journalpl
JBIC. Journal of Biological Inorganic Chemistry
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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