New hallmarks of ageing : a 2022 Copenhagen ageing meeting summary

2022
journal article
review article
122
cris.lastimport.wos2024-04-09T20:53:44Z
dc.abstract.enGenomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the "old" and "new" hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.pl
dc.affiliationPion Prorektora ds. badań naukowych : Jagiellońskie Centrum Rozwoju Lekówpl
dc.cm.id109834pl
dc.cm.idOmegaUJCM9e1b1fe446114221b13f17807687294bpl
dc.contributor.authorSchmauck-Medina, Tomaspl
dc.contributor.authorMoliere, Adrianpl
dc.contributor.authorLautrup, Sofiepl
dc.contributor.authorZhang, Jianyingpl
dc.contributor.authorChłopicki, Stefan - 128995 pl
dc.contributor.authorMadsen, Helena Borlandpl
dc.contributor.authorCao, Shuqinpl
dc.contributor.authorSoendenbroe, Casperpl
dc.contributor.authorMansell, Elspl
dc.contributor.authorVestergaard, Mark Bitschpl
dc.contributor.authorLi, Zhiquanpl
dc.contributor.authorShiloh, Yosefpl
dc.contributor.authorOpresko, Patricia L.pl
dc.contributor.authorEgly, Jean-Marcpl
dc.contributor.authorKirkwood, Thomaspl
dc.contributor.authorVerdin, Ericpl
dc.contributor.authorBohr, Vilhelm A.pl
dc.contributor.authorCox, Lynne S.pl
dc.contributor.authorStevnsner, Tinnapl
dc.contributor.authorRasmussen, Lene Juelpl
dc.contributor.authorFang, Evandro F.pl
dc.date.accession2022-10-18pl
dc.date.accessioned2022-11-03T10:51:10Z
dc.date.available2022-11-03T10:51:10Z
dc.date.issued2022pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number16pl
dc.description.physical6829-6839pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume14pl
dc.identifier.doi10.18632/aging.204248pl
dc.identifier.eissn1945-4589pl
dc.identifier.issn1945-4589pl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/303202
dc.identifier.weblinkhttps://www.aging-us.com/article/204248/textpl
dc.languageengpl
dc.language.containerengpl
dc.pbn.affiliationDziedzina nauk medycznych i nauk o zdrowiu : nauki medycznepl
dc.rightsUdzielam licencji. Uznanie autorstwa 3.0 Polska*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/legalcode*
dc.share.typeOtwarte czasopismo
dc.subtypeReviewArticlepl
dc.titleNew hallmarks of ageing : a 2022 Copenhagen ageing meeting summarypl
dc.title.journalAging-USpl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T20:53:44Z
dc.abstract.enpl
Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the "old" and "new" hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.
dc.affiliationpl
Pion Prorektora ds. badań naukowych : Jagiellońskie Centrum Rozwoju Leków
dc.cm.idpl
109834
dc.cm.idOmegapl
UJCM9e1b1fe446114221b13f17807687294b
dc.contributor.authorpl
Schmauck-Medina, Tomas
dc.contributor.authorpl
Moliere, Adrian
dc.contributor.authorpl
Lautrup, Sofie
dc.contributor.authorpl
Zhang, Jianying
dc.contributor.authorpl
Chłopicki, Stefan - 128995
dc.contributor.authorpl
Madsen, Helena Borland
dc.contributor.authorpl
Cao, Shuqin
dc.contributor.authorpl
Soendenbroe, Casper
dc.contributor.authorpl
Mansell, Els
dc.contributor.authorpl
Vestergaard, Mark Bitsch
dc.contributor.authorpl
Li, Zhiquan
dc.contributor.authorpl
Shiloh, Yosef
dc.contributor.authorpl
Opresko, Patricia L.
dc.contributor.authorpl
Egly, Jean-Marc
dc.contributor.authorpl
Kirkwood, Thomas
dc.contributor.authorpl
Verdin, Eric
dc.contributor.authorpl
Bohr, Vilhelm A.
dc.contributor.authorpl
Cox, Lynne S.
dc.contributor.authorpl
Stevnsner, Tinna
dc.contributor.authorpl
Rasmussen, Lene Juel
dc.contributor.authorpl
Fang, Evandro F.
dc.date.accessionpl
2022-10-18
dc.date.accessioned
2022-11-03T10:51:10Z
dc.date.available
2022-11-03T10:51:10Z
dc.date.issuedpl
2022
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
16
dc.description.physicalpl
6829-6839
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
14
dc.identifier.doipl
10.18632/aging.204248
dc.identifier.eissnpl
1945-4589
dc.identifier.issnpl
1945-4589
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/303202
dc.identifier.weblinkpl
https://www.aging-us.com/article/204248/text
dc.languagepl
eng
dc.language.containerpl
eng
dc.pbn.affiliationpl
Dziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne
dc.rights*
Udzielam licencji. Uznanie autorstwa 3.0 Polska
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/3.0/legalcode
dc.share.type
Otwarte czasopismo
dc.subtypepl
ReviewArticle
dc.titlepl
New hallmarks of ageing : a 2022 Copenhagen ageing meeting summary
dc.title.journalpl
Aging-US
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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