Surface modification of pollen-shape carriers for dry powder inhalation through surface etching

2014
journal article
article
4
cris.lastimport.wos2024-04-09T18:54:09Z
dc.abstract.enSurface modification of pollen-shape hydroxyapatite (HA) carriers is achieved using surface etching technique. Characterization of HA carriers before and after etching are performed by scanning electron microscopy (SEM), Carr’s compressibility index (CI), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). Four surface etching temperatures are tested but only the particles etched at 40 and 50 °C are found satisfactory. Proper surface etching allows a reduction of the petal-like structure on the particle surface and improves the crystallinity of the particles. While the reduction of petal-like structure decreases the emitted dose (ED) of the drug particles, an increase in fine particle fraction (FPF) can be attained owing to the improvement in drug liberation. An increase in the air flow rate, however, decreases the significance of particle surface morphology and the difference in FPF among the use of different carrier particles diminishes. Surface etching technique is found to have good potential as an economical process to improve dry powder inhalation efficiency through surface modification.pl
dc.affiliationWydział Farmaceutyczny : Zakład Technologii Postaci Leku i Biofarmacjipl
dc.cm.id69993
dc.contributor.authorNguyen, Thi Quynh Ngocpl
dc.contributor.authorGiam, Hung Loongpl
dc.contributor.authorWang, Yabopl
dc.contributor.authorPacławski, Adampl
dc.contributor.authorSzlęk, Jakub - 162262 pl
dc.contributor.authorMendyk, Aleksander - 130937 pl
dc.contributor.authorShao, Yu-Hsuanpl
dc.contributor.authorLau, Raymondpl
dc.date.accessioned2015-02-11T13:42:55Z
dc.date.available2015-02-11T13:42:55Z
dc.date.issued2014pl
dc.description.number51pl
dc.description.physical19943-19950pl
dc.description.volume53pl
dc.identifier.doi10.1021/ie502980kpl
dc.identifier.eissn1520-5045pl
dc.identifier.issn0888-5885pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/3027
dc.languageengpl
dc.language.containerengpl
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.uri*
dc.subtypeArticlepl
dc.titleSurface modification of pollen-shape carriers for dry powder inhalation through surface etchingpl
dc.title.journalIndustrial & Engineering Chemistry Researchpl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T18:54:09Z
dc.abstract.enpl
Surface modification of pollen-shape hydroxyapatite (HA) carriers is achieved using surface etching technique. Characterization of HA carriers before and after etching are performed by scanning electron microscopy (SEM), Carr’s compressibility index (CI), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). Four surface etching temperatures are tested but only the particles etched at 40 and 50 °C are found satisfactory. Proper surface etching allows a reduction of the petal-like structure on the particle surface and improves the crystallinity of the particles. While the reduction of petal-like structure decreases the emitted dose (ED) of the drug particles, an increase in fine particle fraction (FPF) can be attained owing to the improvement in drug liberation. An increase in the air flow rate, however, decreases the significance of particle surface morphology and the difference in FPF among the use of different carrier particles diminishes. Surface etching technique is found to have good potential as an economical process to improve dry powder inhalation efficiency through surface modification.
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Technologii Postaci Leku i Biofarmacji
dc.cm.id
69993
dc.contributor.authorpl
Nguyen, Thi Quynh Ngoc
dc.contributor.authorpl
Giam, Hung Loong
dc.contributor.authorpl
Wang, Yabo
dc.contributor.authorpl
Pacławski, Adam
dc.contributor.authorpl
Szlęk, Jakub - 162262
dc.contributor.authorpl
Mendyk, Aleksander - 130937
dc.contributor.authorpl
Shao, Yu-Hsuan
dc.contributor.authorpl
Lau, Raymond
dc.date.accessioned
2015-02-11T13:42:55Z
dc.date.available
2015-02-11T13:42:55Z
dc.date.issuedpl
2014
dc.description.numberpl
51
dc.description.physicalpl
19943-19950
dc.description.volumepl
53
dc.identifier.doipl
10.1021/ie502980k
dc.identifier.eissnpl
1520-5045
dc.identifier.issnpl
0888-5885
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/3027
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Dodaję tylko opis bibliograficzny
dc.rights.uri*
dc.subtypepl
Article
dc.titlepl
Surface modification of pollen-shape carriers for dry powder inhalation through surface etching
dc.title.journalpl
Industrial & Engineering Chemistry Research
dc.typepl
JournalArticle
dspace.entity.type
Publication

* The migration of download and view statistics prior to the date of April 8, 2024 is in progress.

Views
1
Views per month

No access

No Thumbnail Available