Temperature dependence of the interaction of prazosin with lipid Langmuir monolayers

2013
journal article
article
14
cris.lastimport.wos2024-04-09T20:50:02Z
dc.abstract.enThe influence of temperature on membrane–prazosin interactions was studied. Prazosin, a quinazoline derivative of 2-furoylpiperazine, is a classic antihypertensive and antiarrhythmic drug. A mixed cholesterol/phospholipid monolayer at the water/air interface was employed as a simplified biomembrane model. Brewster angle microscopy (BAM) was used to visualize the monolayer morphology. It was found that prazosin penetrates Langmuir monolayers and modifies the interactions between membrane components, causing monolayer fluidization. An increase in temperature facilitates penetration of prazosin into the monolayers. Prazosin interacts preferentially with phosphatidylcholine and modifies the morphology of the condensed phase domains of DPPC. In the presence of prazosin, monolayers collapse at lower surface pressures. The difference between the collapse pressures of monolayers on water with and without prazosin increases with temperature.pl
dc.affiliationWydział Farmaceutyczny : Zakład Technologii i Biotechnologii Środków Leczniczychpl
dc.affiliationWydział Chemii : Zakład Chemii Fizycznej i Elektrochemiipl
dc.cm.id59899
dc.contributor.authorGzyl-Malcher, Barbara - 128262 pl
dc.contributor.authorHandzlik, Jadwiga - 129685 pl
dc.contributor.authorKlekowska, Ewelinapl
dc.date.accessioned2015-01-23T13:31:05Z
dc.date.available2015-01-23T13:31:05Z
dc.date.issued2013pl
dc.description.admin[AB] Klekowska, Ewelina 50000141pl
dc.description.physical171-176pl
dc.description.points30pl
dc.description.volume112pl
dc.identifier.doi10.1016/j.colsurfb.2013.07.030pl
dc.identifier.eissn1873-4367pl
dc.identifier.issn0927-7765pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/2716
dc.languageengpl
dc.language.containerengpl
dc.rights.licencebez licencji
dc.subject.enLangmuir monolayerpl
dc.subject.enphospholipidpl
dc.subject.encholesterolpl
dc.subject.endrugpl
dc.subject.encompressibilitypl
dc.subtypeArticlepl
dc.titleTemperature dependence of the interaction of prazosin with lipid Langmuir monolayerspl
dc.title.journalColloids and Surfaces. B, Biointerfacespl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T20:50:02Z
dc.abstract.enpl
The influence of temperature on membrane–prazosin interactions was studied. Prazosin, a quinazoline derivative of 2-furoylpiperazine, is a classic antihypertensive and antiarrhythmic drug. A mixed cholesterol/phospholipid monolayer at the water/air interface was employed as a simplified biomembrane model. Brewster angle microscopy (BAM) was used to visualize the monolayer morphology. It was found that prazosin penetrates Langmuir monolayers and modifies the interactions between membrane components, causing monolayer fluidization. An increase in temperature facilitates penetration of prazosin into the monolayers. Prazosin interacts preferentially with phosphatidylcholine and modifies the morphology of the condensed phase domains of DPPC. In the presence of prazosin, monolayers collapse at lower surface pressures. The difference between the collapse pressures of monolayers on water with and without prazosin increases with temperature.
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Technologii i Biotechnologii Środków Leczniczych
dc.affiliationpl
Wydział Chemii : Zakład Chemii Fizycznej i Elektrochemii
dc.cm.id
59899
dc.contributor.authorpl
Gzyl-Malcher, Barbara - 128262
dc.contributor.authorpl
Handzlik, Jadwiga - 129685
dc.contributor.authorpl
Klekowska, Ewelina
dc.date.accessioned
2015-01-23T13:31:05Z
dc.date.available
2015-01-23T13:31:05Z
dc.date.issuedpl
2013
dc.description.adminpl
[AB] Klekowska, Ewelina 50000141
dc.description.physicalpl
171-176
dc.description.pointspl
30
dc.description.volumepl
112
dc.identifier.doipl
10.1016/j.colsurfb.2013.07.030
dc.identifier.eissnpl
1873-4367
dc.identifier.issnpl
0927-7765
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/2716
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights.licence
bez licencji
dc.subject.enpl
Langmuir monolayer
dc.subject.enpl
phospholipid
dc.subject.enpl
cholesterol
dc.subject.enpl
drug
dc.subject.enpl
compressibility
dc.subtypepl
Article
dc.titlepl
Temperature dependence of the interaction of prazosin with lipid Langmuir monolayers
dc.title.journalpl
Colloids and Surfaces. B, Biointerfaces
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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