The impact of pulmonary regurgitation on right ventricular size and function in patients with repaired tetralogy of Fallot and additional haemodynamic abnormalities

2020
journal article
article
3
dc.abstract.enPurpose: Right ventricular (RV) outflow tract obstruction (RVOTO) was demonstrated to be protective against RV dilatation in patients with repaired tetralogy of Fallot and chronic pulmonary regurgitation (PR). We hypothesised that the presence of additional haemodynamic abnormalities (more than mild tricuspid regurgitation, residual ventricular septal defect) reduces this protective association. Accordingly, we aimed to assess the impact of PR on RV size and function in this population. Material and methods: Consecutive patients with additional haemodynamic abnormalities after tetralogy of Fallot (TOF) repair, who had undergone cardiovascular magnetic resonance, were included. Results: Out of 90 patients studied, 18 individuals (mean age 32.5 ± 10.7 years, 72.2% males) met the inclusion criteria. There were no differences in RV volumes and ejection fraction between patients with and without RVOTO. Neither PR fraction (PRF) nor PR volume (PRV) correlated with RV end-diastolic volume (r = 0.36; p = 0.15 and r = 0.37; p = 0.14, respectively, for PRF and PRV) or RV end-systolic volume (r = 0.2; p = 0.42 and r = 0.19; p = 0.45, respectively, for PRF and PRV). Similarly, no significant correlations were observed between PRF or PRV and RV ejection fraction (r = –0.04; p = 0.87 and r = –0.03; p = 0.9, respectively). Conclusions: Additional haemodynamic abnormalities are associated with the abolition of the protective effect of RVOTO on RV size. There was no significant relationship between measures of PR and RV volumes in patients after TOF repair with concomitant haemodynamic abnormalities. These abnormalities acted as confounding factors in the assessment of the impact of pulmonary regurgitation on RV size and function.pl
dc.contributor.authorŚpiewak, Mateuszpl
dc.contributor.authorPetryka-Mazurkiewicz, Joannapl
dc.contributor.authorMazurkiewicz, Łukaszpl
dc.contributor.authorMiłosz-Wieczorek, Barbarapl
dc.contributor.authorKowalski, Mirosławpl
dc.contributor.authorBiernacka, Elżbieta K.pl
dc.contributor.authorHoffman, Piotrpl
dc.contributor.authorMarczak, Magdalenapl
dc.date.accessioned2020-12-30T17:14:34Z
dc.date.available2020-12-30T17:14:34Z
dc.date.issued2020pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. e611-e612pl
dc.description.physicale607-e612pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume85pl
dc.identifier.doi10.5114/pjr.2020.101058pl
dc.identifier.eissn1899-0967pl
dc.identifier.issn1733-134Xpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/259519
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enpulmonary regurgitationpl
dc.subject.encardiac magnetic resonancepl
dc.subject.enmagnetic resonance imagingpl
dc.subject.entetralogy of Fallotpl
dc.subject.enventricular septal defectpl
dc.subject.entricuspid regurgitationpl
dc.subtypeArticlepl
dc.titleThe impact of pulmonary regurgitation on right ventricular size and function in patients with repaired tetralogy of Fallot and additional haemodynamic abnormalitiespl
dc.title.journalPolish Journal of Radiologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Purpose: Right ventricular (RV) outflow tract obstruction (RVOTO) was demonstrated to be protective against RV dilatation in patients with repaired tetralogy of Fallot and chronic pulmonary regurgitation (PR). We hypothesised that the presence of additional haemodynamic abnormalities (more than mild tricuspid regurgitation, residual ventricular septal defect) reduces this protective association. Accordingly, we aimed to assess the impact of PR on RV size and function in this population. Material and methods: Consecutive patients with additional haemodynamic abnormalities after tetralogy of Fallot (TOF) repair, who had undergone cardiovascular magnetic resonance, were included. Results: Out of 90 patients studied, 18 individuals (mean age 32.5 ± 10.7 years, 72.2% males) met the inclusion criteria. There were no differences in RV volumes and ejection fraction between patients with and without RVOTO. Neither PR fraction (PRF) nor PR volume (PRV) correlated with RV end-diastolic volume (r = 0.36; p = 0.15 and r = 0.37; p = 0.14, respectively, for PRF and PRV) or RV end-systolic volume (r = 0.2; p = 0.42 and r = 0.19; p = 0.45, respectively, for PRF and PRV). Similarly, no significant correlations were observed between PRF or PRV and RV ejection fraction (r = –0.04; p = 0.87 and r = –0.03; p = 0.9, respectively). Conclusions: Additional haemodynamic abnormalities are associated with the abolition of the protective effect of RVOTO on RV size. There was no significant relationship between measures of PR and RV volumes in patients after TOF repair with concomitant haemodynamic abnormalities. These abnormalities acted as confounding factors in the assessment of the impact of pulmonary regurgitation on RV size and function.
dc.contributor.authorpl
Śpiewak, Mateusz
dc.contributor.authorpl
Petryka-Mazurkiewicz, Joanna
dc.contributor.authorpl
Mazurkiewicz, Łukasz
dc.contributor.authorpl
Miłosz-Wieczorek, Barbara
dc.contributor.authorpl
Kowalski, Mirosław
dc.contributor.authorpl
Biernacka, Elżbieta K.
dc.contributor.authorpl
Hoffman, Piotr
dc.contributor.authorpl
Marczak, Magdalena
dc.date.accessioned
2020-12-30T17:14:34Z
dc.date.available
2020-12-30T17:14:34Z
dc.date.issuedpl
2020
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. e611-e612
dc.description.physicalpl
e607-e612
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
85
dc.identifier.doipl
10.5114/pjr.2020.101058
dc.identifier.eissnpl
1899-0967
dc.identifier.issnpl
1733-134X
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/259519
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
pulmonary regurgitation
dc.subject.enpl
cardiac magnetic resonance
dc.subject.enpl
magnetic resonance imaging
dc.subject.enpl
tetralogy of Fallot
dc.subject.enpl
ventricular septal defect
dc.subject.enpl
tricuspid regurgitation
dc.subtypepl
Article
dc.titlepl
The impact of pulmonary regurgitation on right ventricular size and function in patients with repaired tetralogy of Fallot and additional haemodynamic abnormalities
dc.title.journalpl
Polish Journal of Radiology
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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