Biopolymer-based hydrogels as injectable materials for tissue repair scaffolds

2013
journal article
article
29
cris.lastimport.scopus2024-04-07T16:36:54Z
dc.abstract.enThe progress in tissue regeneration is strongly dependent on the development of biocompatible materials with properties resembling those of a native tissue. Also, the application of noninvasive methods of delivering the scaffold into the tissue defect is of great importance. In this study we present a group of biopolymer-based materials as potential injectable scaffolds. In contrast to other studies involving collagen neutralization or additional incubation of gel in genipin solution, we propose collagen and collagen-chitosan gels crosslinked in situ with genipin. Since some parameters of the cells should be considered in the microscale, the steady-state fluorescence anisotropy was applied to study the microenvironment of the gels. To our knowledge we are the first to report on microrheological properties, such as gel time and microviscosity, for this group of hydrogels. Rapid gelation at physiological temperatures found makes these materials of special interest in applications requiring gel injectability. Physico-chemical investigation showed the influence of the crosslinking agent concentration and chitosan addition on the crosslinking degree, swelling ratio, gel microviscosity, and the degradation rate. Strong correlation was revealed between the surface wettability and the viability of cultured mesenchymal stem cells. Cytotoxicity studies indicated that the collagen-chitosan hydrogels showed the best biocompatibility.pl
dc.affiliationWydział Chemii : Zakład Chemii Fizycznej i Elektrochemiipl
dc.affiliationWydział Biologii i Nauk o Ziemi : Instytut Zoologiipl
dc.contributor.authorFiejdasz, Sylwia - 103693 pl
dc.contributor.authorSzczubiałka, Krzysztof - 132218 pl
dc.contributor.authorLewandowska-Łańcucka, Joanna - 200605 pl
dc.contributor.authorOsyczka, Anna - 131214 pl
dc.contributor.authorNowakowska, Maria - 131048 pl
dc.date.accessioned2015-01-16T11:47:25Z
dc.date.available2015-01-16T11:47:25Z
dc.date.issued2013pl
dc.description.number3pl
dc.description.points30pl
dc.description.volume8pl
dc.identifier.articleid035013pl
dc.identifier.doi10.1088/1748-6041/8/3/035013pl
dc.identifier.eissn1748-605Xpl
dc.identifier.issn1748-6041pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/2574
dc.languageengpl
dc.language.containerengpl
dc.rights.licencebez licencji
dc.subtypeArticlepl
dc.titleBiopolymer-based hydrogels as injectable materials for tissue repair scaffoldspl
dc.title.journalBiomedical Materialspl
dc.typeJournalArticlepl
dspace.entity.typePublication

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