Roxithromycin degradation by acidic hydrolysis and photocatalysis

2014
journal article
article
18
dc.abstract.enThe purpose of this work was to study two methods of degradation of roxithromycin: acidic hydrolysis and photocatalytic degradation under illumination with near-UV light in the presence of the TiO2 photosensitizer. For acidic degradation studies a TLC-densitometric method has been developed using TLC aluminium plates precoated with silica gel F 254 and the mobile phase composed of methanol-acetone-ammonia 25% (1:14:0.1, v/v/v) which gives compact spots for roxithromycin and its degradation products. Photocatalytic degradation studies in the presence of TiO2 were monitored by HPLC. The obtained results have shown that both methods of degradation of roxithromycin are quite efficient. Kinetics of the first order photocatalytic degradation reaction follows the Langmuir-Hinshelwood theory for photocatalytic microheterogeneous systems. The chemical structures of the degradation products obtained during acidic degradation and photocatalytic degradation were suggested based on the UPLC-MS/MS technique. The general mechanisms of both processes were proposed.pl
dc.affiliationWydział Chemii : Zakład Chemii Fizycznej i Elektrochemiipl
dc.affiliationWydział Farmaceutyczny : Zakład Chemii Lekówpl
dc.affiliationWydział Farmaceutyczny : Zakład Chemii Analitycznejpl
dc.contributor.authorKwiecień, Anna - 130588 pl
dc.contributor.authorKrzek, Jan - 130468 pl
dc.contributor.authorŻmudzki, Paweł - 214411 pl
dc.contributor.authorMatoga, Urszulapl
dc.contributor.authorDługosz, Maciej - 107462 pl
dc.contributor.authorSzczubiałka, Krzysztof - 132218 pl
dc.contributor.authorNowakowska, Maria - 131048 pl
dc.date.accessioned2015-01-15T11:01:12Z
dc.date.available2015-01-15T11:01:12Z
dc.date.issued2014pl
dc.description.number16pl
dc.description.physical6414-6423pl
dc.description.volume6pl
dc.identifier.doi10.1039/c4ay00708epl
dc.identifier.eissn1759-9679pl
dc.identifier.issn1759-9660pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/2562
dc.languageengpl
dc.language.containerengpl
dc.rights.licencebez licencji
dc.subtypeArticlepl
dc.titleRoxithromycin degradation by acidic hydrolysis and photocatalysispl
dc.title.journalAnalytical Methodspl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
The purpose of this work was to study two methods of degradation of roxithromycin: acidic hydrolysis and photocatalytic degradation under illumination with near-UV light in the presence of the TiO2 photosensitizer. For acidic degradation studies a TLC-densitometric method has been developed using TLC aluminium plates precoated with silica gel F 254 and the mobile phase composed of methanol-acetone-ammonia 25% (1:14:0.1, v/v/v) which gives compact spots for roxithromycin and its degradation products. Photocatalytic degradation studies in the presence of TiO2 were monitored by HPLC. The obtained results have shown that both methods of degradation of roxithromycin are quite efficient. Kinetics of the first order photocatalytic degradation reaction follows the Langmuir-Hinshelwood theory for photocatalytic microheterogeneous systems. The chemical structures of the degradation products obtained during acidic degradation and photocatalytic degradation were suggested based on the UPLC-MS/MS technique. The general mechanisms of both processes were proposed.
dc.affiliationpl
Wydział Chemii : Zakład Chemii Fizycznej i Elektrochemii
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Chemii Leków
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Chemii Analitycznej
dc.contributor.authorpl
Kwiecień, Anna - 130588
dc.contributor.authorpl
Krzek, Jan - 130468
dc.contributor.authorpl
Żmudzki, Paweł - 214411
dc.contributor.authorpl
Matoga, Urszula
dc.contributor.authorpl
Długosz, Maciej - 107462
dc.contributor.authorpl
Szczubiałka, Krzysztof - 132218
dc.contributor.authorpl
Nowakowska, Maria - 131048
dc.date.accessioned
2015-01-15T11:01:12Z
dc.date.available
2015-01-15T11:01:12Z
dc.date.issuedpl
2014
dc.description.numberpl
16
dc.description.physicalpl
6414-6423
dc.description.volumepl
6
dc.identifier.doipl
10.1039/c4ay00708e
dc.identifier.eissnpl
1759-9679
dc.identifier.issnpl
1759-9660
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/2562
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights.licence
bez licencji
dc.subtypepl
Article
dc.titlepl
Roxithromycin degradation by acidic hydrolysis and photocatalysis
dc.title.journalpl
Analytical Methods
dc.typepl
JournalArticle
dspace.entity.type
Publication

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