Liver biochemical abnormalities in adolescent patients with Turner syndrome

2019
journal article
article
5
cris.lastimport.scopus2024-04-24T01:31:16Z
dc.abstract.enObjective: Elevated liver function tests (LFTs) are common in adult Turner syndrome (TS) patients. Data regarding children and adolescents are lacking. To investigate the prevalence of abnormal LFTs in children and adolescents with TS during several years of observation; to evaluate the potential impact of increased body mass index (BMI) and sex hormone replacement therapy (HRT) on LFTs. Methods: The analysis included 100 girls with TS, aged 4-16 years, all of whom were receiving recombinant human growth hormone therapy. A longitudinal study was conducted which included 81 patients. Results: Mean BMI-standard deviation (SD) score of the subjects was 0.63 (SD: 1.53). Forty-four were being treated with HRT. Elevated LFTs were found in 34% of the patients overall (32% not receiving HRT vs 36% on HRT). The relative risk of increased LFTs was not higher in obese vs normal weight [odds ratio (OR): 0.2; 95% confidence interval (CI): 0.1-0.36, p=0.38 vs OR: 0.16; 95% CI: 0.08-0.3, p=0.1]. HRT did not increase the risk of abnormal LFTs activity (OR: 0.8; 95% CI: 0.5-1.2, p=0.37 vs OR: 0.7; 95% CI: 0.4-1.1, p=0.27). During the follow-up period (mean±SD=4.31±0.82 years), no patient developed overt liver disease. There was no significant increase nor decrease of abnormal LFT frequency in the subsequent years of follow up. Conclusion: Constantly elevated LFTs in TS are common in children and adolescents with TS. However the causes and clinical significance remain unclear. This study suggests that obesity and HRT do not increase the risk of elevated LFTs.pl
dc.affiliationWydział Lekarski : Instytut Pediatriipl
dc.cm.date2020-12-02
dc.cm.id94580
dc.contributor.authorWójcik, Małgorzata - 152478 pl
dc.contributor.authorRuszała, Anna - 148561 pl
dc.contributor.authorJanuś, Dominika - 129843 pl
dc.contributor.authorStarzyk, Jerzy - 133488 pl
dc.date.accession2020-02-17pl
dc.date.accessioned2020-12-02T10:07:31Zpl
dc.date.available2020-12-02T10:07:31Zpl
dc.date.issued2019pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number4pl
dc.description.physical395-399pl
dc.description.points40pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume11pl
dc.identifier.doi10.4274/jcrpe.galenos.2019.2018.0271pl
dc.identifier.eissn1308-5735pl
dc.identifier.issn1308-5727pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/255929
dc.identifier.weblinkhttp://www.jcrpe.org/archives/archive-detail/article-preview/liver-biochemical-abnormalities-in-adolescent-pati/27600pl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enTurner syndromepl
dc.subject.enchildrenpl
dc.subject.enliverpl
dc.subject.enestrogenpl
dc.subtypeArticlepl
dc.titleLiver biochemical abnormalities in adolescent patients with Turner syndromepl
dc.title.journalJCRPE Journal of Clinical Research in Pediatric Endocrinologypl
dc.typeJournalArticlepl
dspace.entity.typePublication

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