A role of hydrogen peroxide producing commensal bacteria present in colon of adolescents with inflammatory bowel disease in perpetuation of the inflammatory process

2009
journal article
article
dc.abstract.enBacteria in the gut play a central role in the initiation and progress of inflammatory bowel disease (IBD). This study was prepared to elucidate the role in the inflammatory process of the bacterial species which are able to produce hydrogen peroxide, present in samples taken from colon lesions in adolescents with inflammatory bowel disease. Fifty eight adolescents were enrolled into the study from January 2004 to October 2006 in Cracow, Poland. Biopsies and stool samples were collected. Bacteriological examinations and measurements of hydrogen peroxide production by enterococci, streptococci and lactobacilli were performed. For the first time it has been shown here that HP producing bacteria may contribute to increased amounts of hydrogen peroxide in the inflamed mucosa of Crohn’s disease and ulcerative colitis patients. Moreover, we have been able to demonstrate an increase of total populations of aerobic bacteria but not anaerobes in the studied samples of mucosa of adolescents with inflammatory bowel disease which is an indirect evidence of higher oxygen tension present in inflamed tissues in IBD. We have also been able to demonstrate the direct relationship between presence of blood in stools of IBD adolescents and increased populations of Enterobacteriaceae but not streptococci in samples of colon mucosa. It is, therefore, possible that different products of Enterobacteriaceae and especially their lipopolysaccharides may also contribute to perpetuation of the chronic colon inflammation.pl
dc.affiliationWydział Lekarski : Zakład Bakteriologii,Ekologii Drobnoustrojów i Parazytologiipl
dc.affiliationWydział Lekarski : Instytut Pediatriipl
dc.contributor.authorStrus, Magdalena - 133523 pl
dc.contributor.authorGosiewski, Tomasz - 129569 pl
dc.contributor.authorFyderek, Krzysztof - 129406 pl
dc.contributor.authorWędrychowicz, Andrzej - 133750 pl
dc.contributor.authorKowalska-Duplaga, Kinga - 130356 pl
dc.contributor.authorKochan, Piotr - 130192 pl
dc.contributor.authorAdamski, Pawełpl
dc.contributor.authorHeczko, Piotr - 129700 pl
dc.date.accession2016-04-20pl
dc.date.accessioned2016-04-20T14:53:44Z
dc.date.available2016-04-20T14:53:44Z
dc.date.issued2009pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.numbersuppl. 6pl
dc.description.physical49-54pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume60pl
dc.identifier.eissn1899-1505pl
dc.identifier.issn0867-5910pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/24400
dc.identifier.weblinkhttp://jpp.krakow.pl/journal/archive/12_09_s6/pdf/49_12_09_s6_article.pdfpl
dc.languageengpl
dc.language.containerengpl
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.licenceOTHER
dc.rights.uri*
dc.share.typeotwarte czasopismo
dc.subject.enhydrogen peroxidepl
dc.subject.eninflammatory bowel diseasepl
dc.subject.enulcerative colitispl
dc.subject.enCrohn's diseasepl
dc.subject.enaerobic bacteriapl
dc.subject.enLactobacilluspl
dc.subtypeArticlepl
dc.titleA role of hydrogen peroxide producing commensal bacteria present in colon of adolescents with inflammatory bowel disease in perpetuation of the inflammatory processpl
dc.title.journalJournal of Physiology and Pharmacologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
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