AM3 inhibits LPS-induced iNOS expression in mice

2005
journal article
article
11
cris.lastimport.scopus2024-04-24T03:26:48Z
cris.lastimport.wos2024-04-09T20:01:41Z
dc.abstract.enWe have analyzed the effect of a patented glycoconjugate of natural origin, AM3 (commercially available under the name Inmunoferon) in the expression of iNOS induced by administration of LPS in mice. We have observed that oral treatment with the drug daily for 6 days reduced the levels of expression of iNOS induced by an intravenous pulse of LPS. This effect was significant in the lungs and kidneys, but it was much more marked in the liver. In addition, the levels of nitric oxide in serum were clearly decreased upon treatment with AM3. Together, these results suggest that AM3 modulates the nitric oxide response and points to a possible role for AM3 in the control of the inflammatory response.pl
dc.affiliationWydział Chemii : Zakład Chemii Nieorganicznejpl
dc.contributor.authorMajano, Pedropl
dc.contributor.authorAlonso-Lebrero, José Luispl
dc.contributor.authorKyzioł, Agnieszka - 147927 pl
dc.contributor.authorMartín-Vichez, Samuelpl
dc.contributor.authorMolina-Jiménez, Franciscapl
dc.contributor.authorBrieva, Aurorapl
dc.contributor.authorPivel, Juan Pablopl
dc.contributor.authorGonzález, Salvadorpl
dc.contributor.authorLópez-Cabrera, Manuelpl
dc.contributor.authorMoreno-Otero, Ricardopl
dc.date.accessioned2014-12-20T10:59:05Z
dc.date.available2014-12-20T10:59:05Z
dc.date.issued2005pl
dc.description.additionalNa publikacji autorka Kyzioł Agnieszka podpisana jako Jańczyk Agnieszka.pl
dc.description.number7-8pl
dc.description.physical1165-1170pl
dc.description.volume5pl
dc.identifier.doi10.1016/j.intimp.2005.02.009pl
dc.identifier.eissn1878-1705pl
dc.identifier.issn1567-5769pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/2389
dc.languageengpl
dc.language.containerengpl
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.licencebez licencji
dc.rights.uri*
dc.subject.ennitric oxidepl
dc.subject.eninmunoferonpl
dc.subject.enAM3pl
dc.subject.enanti-inflammatory responsepl
dc.subject.eniNOSpl
dc.subtypeArticlepl
dc.titleAM3 inhibits LPS-induced iNOS expression in micepl
dc.title.journalInternational Immunopharmacologypl
dc.typeJournalArticlepl
dspace.entity.typePublication

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