A comprehensive approach to study liver tissue : spectroscopic imaging and histochemical staining

2013
journal article
article
8
dc.abstract.enThe liver, due to its central role in the regulation of metabolism and multiplicity of its other functions, is exposed to a high number of pathogenic factors. Non-Alcoholic Fatty Liver Disease (NAFLD), manifested mainly by changes in liver's lipid profile, represent one of the most frequently occurring liver pathology, that is often underestimated at an early stage of its development. The pathogenesis as well as the treatment of NAFLD has not been fully established yet. The difficulty associated with this arises from the need to detect very subtle changes. With regard to fulfilling these expectations, from all available research methods vibrational spectroscopic imaging techniques attract special attention, as they possess a great potential to detect even minor variation in chemical composition of the sample. The specificity of infrared imaging and Raman mapping along with their complementarity provides the ability to obtain comprehensive information on the molecular level. Here we present an approach for the study of liver tissue based on the simultaneous application of vibrational spectroscopic imaging and multirivate data analysis combined with histochemical staining.pl
dc.affiliationWydział Chemii : Zakład Fizyki Chemicznejpl
dc.affiliationPion Rektora : Jagiellońskie Centrum Rozwoju Lekówpl
dc.affiliationWydział Lekarski : Zakład Farmakologiipl
dc.contributor.authorKochan, Kamila - 151367 pl
dc.contributor.authorMaślak, Edyta - 211387 pl
dc.contributor.authorKostogrys, Renata - 102696 pl
dc.contributor.authorChłopicki, Stefan - 128995 pl
dc.contributor.authorBarańska, Małgorzata - 127224 pl
dc.date.accessioned2015-11-19T12:59:16Z
dc.date.available2015-11-19T12:59:16Z
dc.date.issued2013pl
dc.description.number4pl
dc.description.physical331-337pl
dc.description.publication0,8pl
dc.description.volume2pl
dc.identifier.doi10.3233/BSI-130050pl
dc.identifier.eissn2212-8808pl
dc.identifier.issn2212-8794pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/16933
dc.languageengpl
dc.language.containerengpl
dc.rights.licencebez licencji
dc.subject.enliverpl
dc.subject.enRaman mappingpl
dc.subject.enlipidspl
dc.subject.enFT-IRpl
dc.subject.encluster analysispl
dc.subject.enimagingpl
dc.subject.enstainingpl
dc.subject.enOROpl
dc.subtypeArticlepl
dc.titleA comprehensive approach to study liver tissue : spectroscopic imaging and histochemical stainingpl
dc.title.journalBiomedical Spectroscopy and Imagingpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
The liver, due to its central role in the regulation of metabolism and multiplicity of its other functions, is exposed to a high number of pathogenic factors. Non-Alcoholic Fatty Liver Disease (NAFLD), manifested mainly by changes in liver's lipid profile, represent one of the most frequently occurring liver pathology, that is often underestimated at an early stage of its development. The pathogenesis as well as the treatment of NAFLD has not been fully established yet. The difficulty associated with this arises from the need to detect very subtle changes. With regard to fulfilling these expectations, from all available research methods vibrational spectroscopic imaging techniques attract special attention, as they possess a great potential to detect even minor variation in chemical composition of the sample. The specificity of infrared imaging and Raman mapping along with their complementarity provides the ability to obtain comprehensive information on the molecular level. Here we present an approach for the study of liver tissue based on the simultaneous application of vibrational spectroscopic imaging and multirivate data analysis combined with histochemical staining.
dc.affiliationpl
Wydział Chemii : Zakład Fizyki Chemicznej
dc.affiliationpl
Pion Rektora : Jagiellońskie Centrum Rozwoju Leków
dc.affiliationpl
Wydział Lekarski : Zakład Farmakologii
dc.contributor.authorpl
Kochan, Kamila - 151367
dc.contributor.authorpl
Maślak, Edyta - 211387
dc.contributor.authorpl
Kostogrys, Renata - 102696
dc.contributor.authorpl
Chłopicki, Stefan - 128995
dc.contributor.authorpl
Barańska, Małgorzata - 127224
dc.date.accessioned
2015-11-19T12:59:16Z
dc.date.available
2015-11-19T12:59:16Z
dc.date.issuedpl
2013
dc.description.numberpl
4
dc.description.physicalpl
331-337
dc.description.publicationpl
0,8
dc.description.volumepl
2
dc.identifier.doipl
10.3233/BSI-130050
dc.identifier.eissnpl
2212-8808
dc.identifier.issnpl
2212-8794
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/16933
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights.licence
bez licencji
dc.subject.enpl
liver
dc.subject.enpl
Raman mapping
dc.subject.enpl
lipids
dc.subject.enpl
FT-IR
dc.subject.enpl
cluster analysis
dc.subject.enpl
imaging
dc.subject.enpl
staining
dc.subject.enpl
ORO
dc.subtypepl
Article
dc.titlepl
A comprehensive approach to study liver tissue : spectroscopic imaging and histochemical staining
dc.title.journalpl
Biomedical Spectroscopy and Imaging
dc.typepl
JournalArticle
dspace.entity.type
Publication

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