Novel concept in the mechanism of injury and protection of gastric mucosa : role of renina-angiotensin system and active metabolites of angiotensin

2012
journal article
article
32
cris.lastimport.wos2024-04-09T23:38:35Z
dc.abstract.enThe term cytoprotection pioneered by Robert and colleagues has been introduced to describe the remarkable ability of endogenous and exogenous prostaglandins (PGs) to prevent acute gastric hemorrhagic lesions induced by noxious stimuli such as ethanol, bile acids, hiperosmolar solutions and nonsteroidal anti-inflammatory agents such as aspirin. Since that time many factors were implicated to possess gastroprotective properties such as growth factors including epidermal growth factor (EGF) and transforming factor alpha (TGFα), vasodilatory mediators such as nitric oxide (NO) and calcitonin gene related peptide (CGRP) as well as appetite gut hormones including gastrin and cholecystokinin (CCK), leptin and recently ghrelin. This protective action of gut peptides has been attributed to the release of PG but question remains whether another peptide angiotensin, the classic component of the systemic and local renin-angiotensin system (RAS) could be involved in the mechanism of gastric integrity and gastroprotection. After renin stimulation, the circulating angiotensin I is converted to angiotensin II (ANG II) by the activity of the Angiotensin Converting Enzyme (ACE). The ANG II acting via its binding to two major receptor subtypes the ANG type 1 (AT1) and type 2 (AT2) has been shown be activated during stress and to contribute to the pathogenesis of cold stress- and ischemia-reperfusion-induced gastric lesions. All bioactive angiotensin peptides can be generated not only in systemic circulation, but also locally in several tissues and organs. Recently the new functional components of RAS, such as Ang-(1-7), Ang IV, Ang-(1-12) and novel pathways ACE2 have been described suggesting the gastroprotective role for the novel ANG II metabolite, Ang-(1-7). The fact that Ang-(1-7) is produced in excessive amounts in the gastric mucosa of rodents and that pretreatment by Ang-(1-7) exhibits a potent gastroprotective activity against the gastric lesions induced by cold-restraint stress suggests that this and possibly other vasoactive metabolites of ANG II pathway could be involved in the mechanism of gastric integrity and gastroprotection. This review summarizes the novel gastroprotective factors and mechanisms associated with metabolic fate of systemic and local RAS activation with major focus to recent advancement in the angiotensin pathways in the gut integrity.pl
dc.affiliationWydział Lekarski : Zakład Fizjologii Doświadczalnejpl
dc.affiliationWydział Lekarski : Zakład Farmakologiipl
dc.affiliationWydział Lekarski : Pracownia-Zwierzętarnia nr 1pl
dc.affiliationWydział Farmaceutyczny : Zakład Farmakognozjipl
dc.affiliationWydział Lekarski : Katedra Fizjologiipl
dc.contributor.authorBrzozowski, Tomasz - 128893 pl
dc.contributor.authorPtak-Belowska, Agata - 133237 pl
dc.contributor.authorKwiecień, Sławomir - 130590 pl
dc.contributor.authorKrzysiek-Mączka, Gracjana - 130480 pl
dc.contributor.authorStrzałka, Marian - 133528 pl
dc.contributor.authorDrozdowicz, Danuta - 129235 pl
dc.contributor.authorPajdo, Robert - 133071 pl
dc.contributor.authorOlszanecki, Rafał - 133033 pl
dc.contributor.authorKorbut, Ryszard - 130278 pl
dc.contributor.authorKonturek, Stanisław - 214001 pl
dc.contributor.authorPawlik, Wiesław - 133110 pl
dc.date.accessioned2020-04-15T11:15:52Z
dc.date.available2020-04-15T11:15:52Z
dc.date.issued2012pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number1pl
dc.description.physical55-62pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume19pl
dc.identifier.doi10.2174/092986712803413953pl
dc.identifier.eissn1875-533Xpl
dc.identifier.issn0929-8673pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/153859
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeinne
dc.subject.enGastric protectionpl
dc.subject.enrenin-angiotensin systempl
dc.subject.enangiotensin-(1-7)pl
dc.subject.enMas receptorpl
dc.subject.enprostaglandinpl
dc.subject.engastric blood flowpl
dc.subject.ennitric oxidepl
dc.subject.encytoprotection pioneeredpl
dc.subject.enepidermal growth factor (EGF)pl
dc.subject.engastroprotectionpl
dc.subtypeArticlepl
dc.titleNovel concept in the mechanism of injury and protection of gastric mucosa : role of renina-angiotensin system and active metabolites of angiotensinpl
dc.title.journalCurrent Medicinal Chemistrypl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T23:38:35Z
dc.abstract.enpl
The term cytoprotection pioneered by Robert and colleagues has been introduced to describe the remarkable ability of endogenous and exogenous prostaglandins (PGs) to prevent acute gastric hemorrhagic lesions induced by noxious stimuli such as ethanol, bile acids, hiperosmolar solutions and nonsteroidal anti-inflammatory agents such as aspirin. Since that time many factors were implicated to possess gastroprotective properties such as growth factors including epidermal growth factor (EGF) and transforming factor alpha (TGFα), vasodilatory mediators such as nitric oxide (NO) and calcitonin gene related peptide (CGRP) as well as appetite gut hormones including gastrin and cholecystokinin (CCK), leptin and recently ghrelin. This protective action of gut peptides has been attributed to the release of PG but question remains whether another peptide angiotensin, the classic component of the systemic and local renin-angiotensin system (RAS) could be involved in the mechanism of gastric integrity and gastroprotection. After renin stimulation, the circulating angiotensin I is converted to angiotensin II (ANG II) by the activity of the Angiotensin Converting Enzyme (ACE). The ANG II acting via its binding to two major receptor subtypes the ANG type 1 (AT1) and type 2 (AT2) has been shown be activated during stress and to contribute to the pathogenesis of cold stress- and ischemia-reperfusion-induced gastric lesions. All bioactive angiotensin peptides can be generated not only in systemic circulation, but also locally in several tissues and organs. Recently the new functional components of RAS, such as Ang-(1-7), Ang IV, Ang-(1-12) and novel pathways ACE2 have been described suggesting the gastroprotective role for the novel ANG II metabolite, Ang-(1-7). The fact that Ang-(1-7) is produced in excessive amounts in the gastric mucosa of rodents and that pretreatment by Ang-(1-7) exhibits a potent gastroprotective activity against the gastric lesions induced by cold-restraint stress suggests that this and possibly other vasoactive metabolites of ANG II pathway could be involved in the mechanism of gastric integrity and gastroprotection. This review summarizes the novel gastroprotective factors and mechanisms associated with metabolic fate of systemic and local RAS activation with major focus to recent advancement in the angiotensin pathways in the gut integrity.
dc.affiliationpl
Wydział Lekarski : Zakład Fizjologii Doświadczalnej
dc.affiliationpl
Wydział Lekarski : Zakład Farmakologii
dc.affiliationpl
Wydział Lekarski : Pracownia-Zwierzętarnia nr 1
dc.affiliationpl
Wydział Farmaceutyczny : Zakład Farmakognozji
dc.affiliationpl
Wydział Lekarski : Katedra Fizjologii
dc.contributor.authorpl
Brzozowski, Tomasz - 128893
dc.contributor.authorpl
Ptak-Belowska, Agata - 133237
dc.contributor.authorpl
Kwiecień, Sławomir - 130590
dc.contributor.authorpl
Krzysiek-Mączka, Gracjana - 130480
dc.contributor.authorpl
Strzałka, Marian - 133528
dc.contributor.authorpl
Drozdowicz, Danuta - 129235
dc.contributor.authorpl
Pajdo, Robert - 133071
dc.contributor.authorpl
Olszanecki, Rafał - 133033
dc.contributor.authorpl
Korbut, Ryszard - 130278
dc.contributor.authorpl
Konturek, Stanisław - 214001
dc.contributor.authorpl
Pawlik, Wiesław - 133110
dc.date.accessioned
2020-04-15T11:15:52Z
dc.date.available
2020-04-15T11:15:52Z
dc.date.issuedpl
2012
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
1
dc.description.physicalpl
55-62
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
19
dc.identifier.doipl
10.2174/092986712803413953
dc.identifier.eissnpl
1875-533X
dc.identifier.issnpl
0929-8673
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/153859
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
inne
dc.subject.enpl
Gastric protection
dc.subject.enpl
renin-angiotensin system
dc.subject.enpl
angiotensin-(1-7)
dc.subject.enpl
Mas receptor
dc.subject.enpl
prostaglandin
dc.subject.enpl
gastric blood flow
dc.subject.enpl
nitric oxide
dc.subject.enpl
cytoprotection pioneered
dc.subject.enpl
epidermal growth factor (EGF)
dc.subject.enpl
gastroprotection
dc.subtypepl
Article
dc.titlepl
Novel concept in the mechanism of injury and protection of gastric mucosa : role of renina-angiotensin system and active metabolites of angiotensin
dc.title.journalpl
Current Medicinal Chemistry
dc.typepl
JournalArticle
dspace.entity.type
Publication

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