The impact of intrauterine tobacco exposure on the cerebral mass of the neonate based on the measurement of head circumference

2012
journal article
article
14
dc.abstract.enThe objective of the study was to assess cerebral mass, based on head circumfer- ence measurements in neonates exposed to tobacco smoke in utero, and to deter- mine the relative proportions of the cerebral and body mass. The study included 147 neonates born in the period 2003–2004 at the Princess Anna Mazowiecka University Hospita land admitted to the Neonatal and Intensive Care Department of the Medical University in Warsaw. Subjects were divided into three groups on the basis of maternal status as active, passive, or nonsmokers determined by materna lurinary cotinine concentration and a questionnaire. Neonates whose mothers were active smokers throughout the whole period of pregnancy had a lower head circumference and in consequence a lower cerebral mass significantly more frequently when compared with those whose mothers were nonsmokers, P=0.002. (Median difference in cerebral mass was 48.27 g.) The risk of lower cerebral mass was 3.9 (1.4–10.8, CI 95%) in the group of neonates whose mothers actively smoked cigarettes during pregnancy. A negative correlation was seen between cerebral mass and maternal urinary cotinine concentration (correlation coefficient r=−23, P=0.006). The ratio of the cerebral to body mass was similar for neonates in all three groups. Active smoking during pregnancy had a negative effect on the cerebral mass of theneonate, however no such effect was observed in neonates whose mothers were passive smokers. The deficiency in cerebral mass increased with greater smoking intensity. Active smoking by the mother during pregnancy inhibits the growth of the brain as well as that of the body mass of the neonate.pl
dc.affiliationWydział Chemii : Zakład Chemii Analitycznejpl
dc.contributor.authorKról, Marzennapl
dc.contributor.authorFlorek, Ewapl
dc.contributor.authorPiekoszewski, Wojciech - 160149 pl
dc.contributor.authorBokiniec, Renatapl
dc.contributor.authorKornacka, Maria K.pl
dc.date.accession2018-12-03pl
dc.date.accessioned2015-09-07T11:35:10Z
dc.date.available2015-09-07T11:35:10Z
dc.date.issued2012pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number3pl
dc.description.physical243-248pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume2pl
dc.identifier.doi10.1002/brb3.49pl
dc.identifier.eissn2162-3279pl
dc.identifier.projectROD UJ / Ppl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/15356
dc.identifier.weblinkhttps://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.49pl
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 3.0*
dc.rights.licenceCC-BY-NC
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/legalcode*
dc.share.typeotwarte czasopismo
dc.subject.enactive smokingpl
dc.subject.encerebral masspl
dc.subject.enassive smokinpl
dc.subject.encotinine, neonatepl
dc.subject.ensmoker motherpl
dc.subject.enurinepl
dc.subtypeArticlepl
dc.titleThe impact of intrauterine tobacco exposure on the cerebral mass of the neonate based on the measurement of head circumferencepl
dc.title.journalBrain and Behaviorpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
The objective of the study was to assess cerebral mass, based on head circumfer- ence measurements in neonates exposed to tobacco smoke in utero, and to deter- mine the relative proportions of the cerebral and body mass. The study included 147 neonates born in the period 2003–2004 at the Princess Anna Mazowiecka University Hospita land admitted to the Neonatal and Intensive Care Department of the Medical University in Warsaw. Subjects were divided into three groups on the basis of maternal status as active, passive, or nonsmokers determined by materna lurinary cotinine concentration and a questionnaire. Neonates whose mothers were active smokers throughout the whole period of pregnancy had a lower head circumference and in consequence a lower cerebral mass significantly more frequently when compared with those whose mothers were nonsmokers, P=0.002. (Median difference in cerebral mass was 48.27 g.) The risk of lower cerebral mass was 3.9 (1.4–10.8, CI 95%) in the group of neonates whose mothers actively smoked cigarettes during pregnancy. A negative correlation was seen between cerebral mass and maternal urinary cotinine concentration (correlation coefficient r=−23, P=0.006). The ratio of the cerebral to body mass was similar for neonates in all three groups. Active smoking during pregnancy had a negative effect on the cerebral mass of theneonate, however no such effect was observed in neonates whose mothers were passive smokers. The deficiency in cerebral mass increased with greater smoking intensity. Active smoking by the mother during pregnancy inhibits the growth of the brain as well as that of the body mass of the neonate.
dc.affiliationpl
Wydział Chemii : Zakład Chemii Analitycznej
dc.contributor.authorpl
Król, Marzenna
dc.contributor.authorpl
Florek, Ewa
dc.contributor.authorpl
Piekoszewski, Wojciech - 160149
dc.contributor.authorpl
Bokiniec, Renata
dc.contributor.authorpl
Kornacka, Maria K.
dc.date.accessionpl
2018-12-03
dc.date.accessioned
2015-09-07T11:35:10Z
dc.date.available
2015-09-07T11:35:10Z
dc.date.issuedpl
2012
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
3
dc.description.physicalpl
243-248
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
2
dc.identifier.doipl
10.1002/brb3.49
dc.identifier.eissnpl
2162-3279
dc.identifier.projectpl
ROD UJ / P
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/15356
dc.identifier.weblinkpl
https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.49
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 3.0
dc.rights.licence
CC-BY-NC
dc.rights.uri*
http://creativecommons.org/licenses/by-nc/3.0/legalcode
dc.share.type
otwarte czasopismo
dc.subject.enpl
active smoking
dc.subject.enpl
cerebral mass
dc.subject.enpl
assive smokin
dc.subject.enpl
cotinine, neonate
dc.subject.enpl
smoker mother
dc.subject.enpl
urine
dc.subtypepl
Article
dc.titlepl
The impact of intrauterine tobacco exposure on the cerebral mass of the neonate based on the measurement of head circumference
dc.title.journalpl
Brain and Behavior
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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