Neuropeptide B and neuropeptide W as new serum predictors of nutritional status and of clinical outcomes in pediatric patients with type 1 diabetes mellitus treated with the use of pens or insulin pumps

2019
journal article
article
4
dc.abstract.enIntroduction: The aim of our study was to determine the relationship between neuropeptide B (NPB), neuropeptide W (NPW), nutritional and antioxidant status and selected fat- and bone-derived factors in type 1 diabetes mellitus (T1DM) treated using pens (T1DM pen group) or insulin pumps (T1DM pump group) in order to investigate the potential role of NPB and NPW in the clinical outcomes of T1DM. Material and methods: Fifty-eight patients with T1DM and twenty-five healthy controls (CONTR) participated in the study. Assessments of NPB, NPW, total antioxidant status (TAS), leptin, adiponectin, osteocalcin, and free soluble receptor activator for nuclear factor κB (free sRANKL) were conducted. Results: NPB, NPW, leptin, and TAS were lower (by 33%, p < 0.013; 34%, p < 0.008; 290%, p < 0.00004; 21%, p < 0.05; respectively), while adiponectin was by 51% higher (p < 0.006) in T1DM vs. CONTR, while osteocalcin and free sRANKL levels were similar in both groups. NPW was lower in the T1DM pen group both vs. the T1DM pump group (36% lower, p < 0.0009) and vs. the CONTR group (35% lower, p < 0.002). In the T1DM pen group, but not in the T1DM pump group or the CONTR group, the Cole index and TAS levels explain (besides NPB) the variation in NPW values. ROC curves showed that serum levels of leptin, adiponectin, NPB and NPW (but not osteocalcin or free sRANKL) were predictive indicators for T1DM. Conclusions: Measurements of NPB and NPW, besides leptin and adiponectin, are worth considering in the detailed prognosis of nutritional status in T1DM, primarily in the T1DM pen-treated population.pl
dc.affiliationWydział Lekarski : Instytut Pediatriipl
dc.cm.date2020-01-07
dc.cm.id93730
dc.contributor.authorGrzelak, Teresapl
dc.contributor.authorWędrychowicz, Anna - 133751 pl
dc.contributor.authorGrupińska, Joannapl
dc.contributor.authorPełczyńska, Martapl
dc.contributor.authorSperling, Marcelinapl
dc.contributor.authorMikulska, Aniceta A.pl
dc.contributor.authorNaughton, Violettapl
dc.contributor.authorCzyżewska, Krystynapl
dc.date.accessioned2020-01-17T10:07:53Z
dc.date.available2020-01-17T10:07:53Z
dc.date.issued2019pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number3pl
dc.description.physical619-631pl
dc.description.points70pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume15pl
dc.identifier.doi10.5114/aoms.2018.75818pl
dc.identifier.eissn1896-9151pl
dc.identifier.issn1734-1922pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/145855
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-SA
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.eninsulinpl
dc.subject.enbiochemistrypl
dc.subject.entype 1 diabetes mellituspl
dc.subtypeArticlepl
dc.titleNeuropeptide B and neuropeptide W as new serum predictors of nutritional status and of clinical outcomes in pediatric patients with type 1 diabetes mellitus treated with the use of pens or insulin pumpspl
dc.title.journalArchives of Medical Sciencepl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Introduction: The aim of our study was to determine the relationship between neuropeptide B (NPB), neuropeptide W (NPW), nutritional and antioxidant status and selected fat- and bone-derived factors in type 1 diabetes mellitus (T1DM) treated using pens (T1DM pen group) or insulin pumps (T1DM pump group) in order to investigate the potential role of NPB and NPW in the clinical outcomes of T1DM. Material and methods: Fifty-eight patients with T1DM and twenty-five healthy controls (CONTR) participated in the study. Assessments of NPB, NPW, total antioxidant status (TAS), leptin, adiponectin, osteocalcin, and free soluble receptor activator for nuclear factor κB (free sRANKL) were conducted. Results: NPB, NPW, leptin, and TAS were lower (by 33%, p < 0.013; 34%, p < 0.008; 290%, p < 0.00004; 21%, p < 0.05; respectively), while adiponectin was by 51% higher (p < 0.006) in T1DM vs. CONTR, while osteocalcin and free sRANKL levels were similar in both groups. NPW was lower in the T1DM pen group both vs. the T1DM pump group (36% lower, p < 0.0009) and vs. the CONTR group (35% lower, p < 0.002). In the T1DM pen group, but not in the T1DM pump group or the CONTR group, the Cole index and TAS levels explain (besides NPB) the variation in NPW values. ROC curves showed that serum levels of leptin, adiponectin, NPB and NPW (but not osteocalcin or free sRANKL) were predictive indicators for T1DM. Conclusions: Measurements of NPB and NPW, besides leptin and adiponectin, are worth considering in the detailed prognosis of nutritional status in T1DM, primarily in the T1DM pen-treated population.
dc.affiliationpl
Wydział Lekarski : Instytut Pediatrii
dc.cm.date
2020-01-07
dc.cm.id
93730
dc.contributor.authorpl
Grzelak, Teresa
dc.contributor.authorpl
Wędrychowicz, Anna - 133751
dc.contributor.authorpl
Grupińska, Joanna
dc.contributor.authorpl
Pełczyńska, Marta
dc.contributor.authorpl
Sperling, Marcelina
dc.contributor.authorpl
Mikulska, Aniceta A.
dc.contributor.authorpl
Naughton, Violetta
dc.contributor.authorpl
Czyżewska, Krystyna
dc.date.accessioned
2020-01-17T10:07:53Z
dc.date.available
2020-01-17T10:07:53Z
dc.date.issuedpl
2019
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
3
dc.description.physicalpl
619-631
dc.description.pointspl
70
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
15
dc.identifier.doipl
10.5114/aoms.2018.75818
dc.identifier.eissnpl
1896-9151
dc.identifier.issnpl
1734-1922
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/145855
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-SA
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
insulin
dc.subject.enpl
biochemistry
dc.subject.enpl
type 1 diabetes mellitus
dc.subtypepl
Article
dc.titlepl
Neuropeptide B and neuropeptide W as new serum predictors of nutritional status and of clinical outcomes in pediatric patients with type 1 diabetes mellitus treated with the use of pens or insulin pumps
dc.title.journalpl
Archives of Medical Science
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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