Chemokine RANTES and IL-1â in mild therapeutic hypothermia-treated patients after out-of-hospital sudden cardiac arrest

2019
journal article
article
6
dc.abstract.enIntroduction: CCL5/RANTES and IL-1β, which regulate the immune response, may have an impact on survival in patients with acute coronary syndrome (ACS) and sudden cardiac arrest (SCA). Aim: To evaluate levels of CCL5/RANTES and IL-1β in patients with ACS complicated by SCA, treated with coronary angioplasty (PCI) and mild therapeutic hypothermia (MTH), and these chemokines’ impact on the 30- and 180-day survival. Material and methods: Thirty-three unconscious patients admitted after SCA with ACS underwent PCI and MTH treatment. CCL5/RANTES and IL-1β were evaluated on admission (T0), at 12–24 h (T1) and at 48–72 h (T2). All-cause mortality was recorded at 30 and 180 days. Results: We observed a statistically significant decrease in median levels of CCL/RANTES at T0, T1 and T2 (24.69 ng/ml vs. 3.89 ng/ml vs. 2.71 ng/ml; p < 0.001), and significant differences in median levels of IL-1β (0.196 pg/ml vs. 0.171 pg/ml vs. 0.214 pg/ml; p = 0.034). Initial levels of CCL5/RANTES and IL-1β correlated significantly (r = –0.360; p = 0.045). At T2, CCL5/RANTES correlated with the maximum levels of hs-TnT and CK-MB (r = –0.594; p < 0.001 and r = –0.389; p = 0.030), and at T0 with BNP (r = –0.521; p = 0.003). Mortality rate at 30 days and 180 days was 18.2% and 45.5%, respectively. At 30 days, we observed a trend to significance for IL-1β at T0 and T1 (p = 0.078 and p = 0.079), but not for CCL5/RANTES (p = 0.284 and p = 0.351). For 180-day survival curves, only the IL-1β level at T1 was associated with mortality (p = 0.028). Conclusions: Although CCL5/RANTES levels correlate with cardiac injury and heart failure markers and they decrease during MTH, they failed to predict early and late mortality. In contrast, IL-1β level was associated with 180-day survival.pl
dc.affiliationWydział Lekarski : Instytut Kardiologiipl
dc.affiliationWydział Lekarski : Katedra Chorób Wewnętrznych i Medycyny Wsipl
dc.cm.date2020-01-07
dc.cm.id93550
dc.contributor.authorPodolec, Jakub - 133184 pl
dc.contributor.authorTrąbka-Zawicki, Aleksanderpl
dc.contributor.authorBadacz, Rafał - 148377 pl
dc.contributor.authorSiedliński, Mateusz - 214569 pl
dc.contributor.authorTomala, Marekpl
dc.contributor.authorBartuś, Krzysztof - 200764 pl
dc.contributor.authorLegutko, Jacek - 130630 pl
dc.contributor.authorPrzewłocki, Tadeusz - 133225 pl
dc.contributor.authorŻmudka, Krzysztof - 133948 pl
dc.contributor.authorKabłak-Ziembicka, Anna - 129937 pl
dc.date.accessioned2020-01-17T10:07:49Z
dc.date.available2020-01-17T10:07:49Z
dc.date.issued2019pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number1 (55)pl
dc.description.physical98-106pl
dc.description.points40pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume15pl
dc.identifier.doi10.5114/aic.2019.83653pl
dc.identifier.eissn1897-4295pl
dc.identifier.issn1734-9338pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/145743
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-SA
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enchemokine RANTESpl
dc.subject.enIL-1βpl
dc.subject.enmild therapeutic hypothermiapl
dc.subject.ensudden cardiac arrestpl
dc.subtypeArticlepl
dc.titleChemokine RANTES and IL-1â in mild therapeutic hypothermia-treated patients after out-of-hospital sudden cardiac arrestpl
dc.title.journalPostępy w Kardiologii Interwencyjnejpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Introduction: CCL5/RANTES and IL-1β, which regulate the immune response, may have an impact on survival in patients with acute coronary syndrome (ACS) and sudden cardiac arrest (SCA). Aim: To evaluate levels of CCL5/RANTES and IL-1β in patients with ACS complicated by SCA, treated with coronary angioplasty (PCI) and mild therapeutic hypothermia (MTH), and these chemokines’ impact on the 30- and 180-day survival. Material and methods: Thirty-three unconscious patients admitted after SCA with ACS underwent PCI and MTH treatment. CCL5/RANTES and IL-1β were evaluated on admission (T0), at 12–24 h (T1) and at 48–72 h (T2). All-cause mortality was recorded at 30 and 180 days. Results: We observed a statistically significant decrease in median levels of CCL/RANTES at T0, T1 and T2 (24.69 ng/ml vs. 3.89 ng/ml vs. 2.71 ng/ml; p < 0.001), and significant differences in median levels of IL-1β (0.196 pg/ml vs. 0.171 pg/ml vs. 0.214 pg/ml; p = 0.034). Initial levels of CCL5/RANTES and IL-1β correlated significantly (r = –0.360; p = 0.045). At T2, CCL5/RANTES correlated with the maximum levels of hs-TnT and CK-MB (r = –0.594; p < 0.001 and r = –0.389; p = 0.030), and at T0 with BNP (r = –0.521; p = 0.003). Mortality rate at 30 days and 180 days was 18.2% and 45.5%, respectively. At 30 days, we observed a trend to significance for IL-1β at T0 and T1 (p = 0.078 and p = 0.079), but not for CCL5/RANTES (p = 0.284 and p = 0.351). For 180-day survival curves, only the IL-1β level at T1 was associated with mortality (p = 0.028). Conclusions: Although CCL5/RANTES levels correlate with cardiac injury and heart failure markers and they decrease during MTH, they failed to predict early and late mortality. In contrast, IL-1β level was associated with 180-day survival.
dc.affiliationpl
Wydział Lekarski : Instytut Kardiologii
dc.affiliationpl
Wydział Lekarski : Katedra Chorób Wewnętrznych i Medycyny Wsi
dc.cm.date
2020-01-07
dc.cm.id
93550
dc.contributor.authorpl
Podolec, Jakub - 133184
dc.contributor.authorpl
Trąbka-Zawicki, Aleksander
dc.contributor.authorpl
Badacz, Rafał - 148377
dc.contributor.authorpl
Siedliński, Mateusz - 214569
dc.contributor.authorpl
Tomala, Marek
dc.contributor.authorpl
Bartuś, Krzysztof - 200764
dc.contributor.authorpl
Legutko, Jacek - 130630
dc.contributor.authorpl
Przewłocki, Tadeusz - 133225
dc.contributor.authorpl
Żmudka, Krzysztof - 133948
dc.contributor.authorpl
Kabłak-Ziembicka, Anna - 129937
dc.date.accessioned
2020-01-17T10:07:49Z
dc.date.available
2020-01-17T10:07:49Z
dc.date.issuedpl
2019
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
1 (55)
dc.description.physicalpl
98-106
dc.description.pointspl
40
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
15
dc.identifier.doipl
10.5114/aic.2019.83653
dc.identifier.eissnpl
1897-4295
dc.identifier.issnpl
1734-9338
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/145743
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-SA
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
chemokine RANTES
dc.subject.enpl
IL-1β
dc.subject.enpl
mild therapeutic hypothermia
dc.subject.enpl
sudden cardiac arrest
dc.subtypepl
Article
dc.titlepl
Chemokine RANTES and IL-1â in mild therapeutic hypothermia-treated patients after out-of-hospital sudden cardiac arrest
dc.title.journalpl
Postępy w Kardiologii Interwencyjnej
dc.typepl
JournalArticle
dspace.entity.type
Publication

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