Comparison of clinical and echocardiographic outcomes and quality of life in patients with severe mitral regurgitation treated by MitraClip implantation or treated conservatively

2018
journal article
article
6
dc.abstract.enIntroduction: The most common alternative method of treatment for patients with severe mitral regurgitation (MR) is the implantation of a MitraClip device. Aim: To evaluate clinical and echocardiographic outcomes and quality of life (QoL) in patients with severe secondary MR, disqualified from surgical intervention, treated by implantation of a MitraClip in comparison to conservative therapy. Material and methods: A total of 33 patients were included. Patients were stratified by treatment method: group A, MitraClip implantation (n = 10); group B, conservative treatment (n = 23). Clinical, echocardiographic, and QoL (EQ-5D-3L, SF-12v2 Health Survey) characteristics were compared at baseline and at follow-up of 8.0 ±2.3 months. Results: In group A, 2 deaths were observed: one patient died 7 days after MitraClip implantation, and the second patient died 4 months after the procedure. No cases of rehospitalization were reported. In group B, 4 (17.4%) deaths and 6 (26.1%) hospitalizations were reported. After MitraClip implantation a significant reduction of the NYHA class (p = 0.02), decrease in grade of MR (p = 0.01), vena contracta width (p = 0.006), effective regurgitant orifice area (EROA) (p = 0.003), regurgitant volume (p = 0.03) and end-diastolic left ventricle diameter (p = 0.02) as well as an improvement in QoL were reported. There were no significant changes in the NYHA class and QoL in the group treated conservatively. In those patients, we observed increased intercommissural mitral annulus diameter (p = 0.03), left atrium diameter (p = 0.002), and right ventricle dimension (p = 0.008), more severe tricuspid regurgitation (p = 0.02) and lower mitral annular plane systolic excursion (p = 0.01). Conclusions: Patients with severe secondary MR treated with the MitraClip achieved a significant reduction in symptoms and MR grade, as well as an improvement in QoL, as compared to patients treated conservatively.pl
dc.affiliationWydział Lekarski : Instytut Kardiologiipl
dc.affiliationWydział Lekarski : Zakład Anatomiipl
dc.cm.date2020-01-07
dc.cm.id91492
dc.contributor.authorKrawczyk-Ożóg, Agatapl
dc.contributor.authorSiudak, Zbigniew - 152463 pl
dc.contributor.authorSorysz, Danutapl
dc.contributor.authorHołda, Mateusz - 203774 pl
dc.contributor.authorPłotek, Annapl
dc.contributor.authorDziewierz, Artur - 241962 pl
dc.contributor.authorGackowski, Andrzej - 159971 pl
dc.contributor.authorDudek, Dariusz - 129271 pl
dc.date.accessioned2020-01-17T10:01:40Z
dc.date.available2020-01-17T10:01:40Z
dc.date.issued2018pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number3 (53)pl
dc.description.physical291-298pl
dc.description.points15pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume14pl
dc.identifier.doi10.5114/aic.2018.78334pl
dc.identifier.eissn1897-4295pl
dc.identifier.issn1734-9338pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/144396
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC-SA
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enMitraClippl
dc.subject.enheart failurepl
dc.subject.enmitral regurgitationpl
dc.subject.enquality of lifepl
dc.subtypeArticlepl
dc.titleComparison of clinical and echocardiographic outcomes and quality of life in patients with severe mitral regurgitation treated by MitraClip implantation or treated conservativelypl
dc.title.journalPostępy w Kardiologii Interwencyjnejpl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Introduction: The most common alternative method of treatment for patients with severe mitral regurgitation (MR) is the implantation of a MitraClip device. Aim: To evaluate clinical and echocardiographic outcomes and quality of life (QoL) in patients with severe secondary MR, disqualified from surgical intervention, treated by implantation of a MitraClip in comparison to conservative therapy. Material and methods: A total of 33 patients were included. Patients were stratified by treatment method: group A, MitraClip implantation (n = 10); group B, conservative treatment (n = 23). Clinical, echocardiographic, and QoL (EQ-5D-3L, SF-12v2 Health Survey) characteristics were compared at baseline and at follow-up of 8.0 ±2.3 months. Results: In group A, 2 deaths were observed: one patient died 7 days after MitraClip implantation, and the second patient died 4 months after the procedure. No cases of rehospitalization were reported. In group B, 4 (17.4%) deaths and 6 (26.1%) hospitalizations were reported. After MitraClip implantation a significant reduction of the NYHA class (p = 0.02), decrease in grade of MR (p = 0.01), vena contracta width (p = 0.006), effective regurgitant orifice area (EROA) (p = 0.003), regurgitant volume (p = 0.03) and end-diastolic left ventricle diameter (p = 0.02) as well as an improvement in QoL were reported. There were no significant changes in the NYHA class and QoL in the group treated conservatively. In those patients, we observed increased intercommissural mitral annulus diameter (p = 0.03), left atrium diameter (p = 0.002), and right ventricle dimension (p = 0.008), more severe tricuspid regurgitation (p = 0.02) and lower mitral annular plane systolic excursion (p = 0.01). Conclusions: Patients with severe secondary MR treated with the MitraClip achieved a significant reduction in symptoms and MR grade, as well as an improvement in QoL, as compared to patients treated conservatively.
dc.affiliationpl
Wydział Lekarski : Instytut Kardiologii
dc.affiliationpl
Wydział Lekarski : Zakład Anatomii
dc.cm.date
2020-01-07
dc.cm.id
91492
dc.contributor.authorpl
Krawczyk-Ożóg, Agata
dc.contributor.authorpl
Siudak, Zbigniew - 152463
dc.contributor.authorpl
Sorysz, Danuta
dc.contributor.authorpl
Hołda, Mateusz - 203774
dc.contributor.authorpl
Płotek, Anna
dc.contributor.authorpl
Dziewierz, Artur - 241962
dc.contributor.authorpl
Gackowski, Andrzej - 159971
dc.contributor.authorpl
Dudek, Dariusz - 129271
dc.date.accessioned
2020-01-17T10:01:40Z
dc.date.available
2020-01-17T10:01:40Z
dc.date.issuedpl
2018
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
3 (53)
dc.description.physicalpl
291-298
dc.description.pointspl
15
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
14
dc.identifier.doipl
10.5114/aic.2018.78334
dc.identifier.eissnpl
1897-4295
dc.identifier.issnpl
1734-9338
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/144396
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC-SA
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
MitraClip
dc.subject.enpl
heart failure
dc.subject.enpl
mitral regurgitation
dc.subject.enpl
quality of life
dc.subtypepl
Article
dc.titlepl
Comparison of clinical and echocardiographic outcomes and quality of life in patients with severe mitral regurgitation treated by MitraClip implantation or treated conservatively
dc.title.journalpl
Postępy w Kardiologii Interwencyjnej
dc.typepl
JournalArticle
dspace.entity.type
Publication

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