Follow-up of parenchymal changes in the thyroid gland with diffuse autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma

2019
journal article
article
cris.lastimport.wos2024-04-09T21:52:07Z
dc.abstract.enPurpose To present the outcomes of ultrasound (US) follow-ups in children with autoimmune thyroid disease who did not have a thyroid nodule on admission but developed papillary thyroid carcinoma (PTC) and to characterize the parenchymal changes in the thyroid gland prior to the development of PTC. Methods A retrospective thyroid US scan review of 327 patients diagnosed with AIT was performed. Forty patients (40/327, 12.2%) presented nodular AIT variant with a normoechogenic background. Eleven patients (11/327, 3.4%, 11/40, 27.5%) presenting this variant were diagnosed with PTC (nine females-mean age 15.3 years; two males aged 11 and 13 years). In five of 11 patients, the suspicious nodule that was later confirmed to be PTC was detected on the initial US at presentation. For the remaining six females (6/11) who developed PTC during the follow-up, we retrospectively analysed their US thyroid scans and these patients were selected for analysis in this study. Results On admission, the US evaluation revealed an enlarged normoechogenic thyroid gland in three patients and a hypoechogenic thyroid gland with fibrosis as indicated by irregular, chaotic hyperechogenic layers in three patients. No thyroid nodules were identified. Ultrasound monitoring revealed increasing echogenicity of the thyroid parenchyma during the follow-up. PTC developed in a mean time of 4.6 years (1 9/12-7 4/12 years) since referral to the outpatient thyroid clinic and 2.9 years (6/12-6 9/12) since the last nodule-free US thyroid scan. Conclusions Sonographic follow-up assessments warrant further exploration as a strategy to determine PTC susceptibility in the paediatric population.pl
dc.affiliationWydział Lekarski : Instytut Pediatriipl
dc.cm.date2020-01-07
dc.cm.id89357
dc.contributor.authorJanuś, Dominika - 129843 pl
dc.contributor.authorWójcik, Małgorzata - 152478 pl
dc.contributor.authorTaczanowska-Niemczuk, Anna - 200536 pl
dc.contributor.authorSołtysiak, Piotr - 255586 pl
dc.contributor.authorWędrychowicz, Anna - 133751 pl
dc.contributor.authorRoztoczyńska, Dorotapl
dc.contributor.authorDrabik, Grażyna - 129218 pl
dc.contributor.authorWyrobek, Łukaszpl
dc.contributor.authorStarzyk, Jerzy - 133488 pl
dc.date.accessioned2020-01-17T09:58:54Z
dc.date.available2020-01-17T09:58:54Z
dc.date.issued2019pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number3pl
dc.description.physical261-270pl
dc.description.points100pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume42pl
dc.identifier.doi10.1007/s40618-018-0909-xpl
dc.identifier.eissn1720-8386
dc.identifier.issn0391-4097pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/143357
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeinne
dc.subject.enautoimmune thyroiditispl
dc.subject.enpapillary thyroid carcinomapl
dc.subject.enultrasonography of thyroid glandpl
dc.subject.ennormoechogenic background of thyroid glandpl
dc.subtypeArticlepl
dc.titleFollow-up of parenchymal changes in the thyroid gland with diffuse autoimmune thyroiditis in children prior to the development of papillary thyroid carcinomapl
dc.title.journalJournal of Endocrinological Investigationpl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T21:52:07Z
dc.abstract.enpl
Purpose To present the outcomes of ultrasound (US) follow-ups in children with autoimmune thyroid disease who did not have a thyroid nodule on admission but developed papillary thyroid carcinoma (PTC) and to characterize the parenchymal changes in the thyroid gland prior to the development of PTC. Methods A retrospective thyroid US scan review of 327 patients diagnosed with AIT was performed. Forty patients (40/327, 12.2%) presented nodular AIT variant with a normoechogenic background. Eleven patients (11/327, 3.4%, 11/40, 27.5%) presenting this variant were diagnosed with PTC (nine females-mean age 15.3 years; two males aged 11 and 13 years). In five of 11 patients, the suspicious nodule that was later confirmed to be PTC was detected on the initial US at presentation. For the remaining six females (6/11) who developed PTC during the follow-up, we retrospectively analysed their US thyroid scans and these patients were selected for analysis in this study. Results On admission, the US evaluation revealed an enlarged normoechogenic thyroid gland in three patients and a hypoechogenic thyroid gland with fibrosis as indicated by irregular, chaotic hyperechogenic layers in three patients. No thyroid nodules were identified. Ultrasound monitoring revealed increasing echogenicity of the thyroid parenchyma during the follow-up. PTC developed in a mean time of 4.6 years (1 9/12-7 4/12 years) since referral to the outpatient thyroid clinic and 2.9 years (6/12-6 9/12) since the last nodule-free US thyroid scan. Conclusions Sonographic follow-up assessments warrant further exploration as a strategy to determine PTC susceptibility in the paediatric population.
dc.affiliationpl
Wydział Lekarski : Instytut Pediatrii
dc.cm.date
2020-01-07
dc.cm.id
89357
dc.contributor.authorpl
Januś, Dominika - 129843
dc.contributor.authorpl
Wójcik, Małgorzata - 152478
dc.contributor.authorpl
Taczanowska-Niemczuk, Anna - 200536
dc.contributor.authorpl
Sołtysiak, Piotr - 255586
dc.contributor.authorpl
Wędrychowicz, Anna - 133751
dc.contributor.authorpl
Roztoczyńska, Dorota
dc.contributor.authorpl
Drabik, Grażyna - 129218
dc.contributor.authorpl
Wyrobek, Łukasz
dc.contributor.authorpl
Starzyk, Jerzy - 133488
dc.date.accessioned
2020-01-17T09:58:54Z
dc.date.available
2020-01-17T09:58:54Z
dc.date.issuedpl
2019
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
3
dc.description.physicalpl
261-270
dc.description.pointspl
100
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
42
dc.identifier.doipl
10.1007/s40618-018-0909-x
dc.identifier.eissn
1720-8386
dc.identifier.issnpl
0391-4097
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/143357
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
inne
dc.subject.enpl
autoimmune thyroiditis
dc.subject.enpl
papillary thyroid carcinoma
dc.subject.enpl
ultrasonography of thyroid gland
dc.subject.enpl
normoechogenic background of thyroid gland
dc.subtypepl
Article
dc.titlepl
Follow-up of parenchymal changes in the thyroid gland with diffuse autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma
dc.title.journalpl
Journal of Endocrinological Investigation
dc.typepl
JournalArticle
dspace.entity.type
Publication

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