Tumor expression of survivin, p53, cyclin D1, osteopontin and fibronectin in predicting the response to neo-adjuvant chemotherapy in children with advanced malignant peripheral nerve sheath tumor

2018
journal article
article
13
cris.lastimport.wos2024-04-09T21:58:49Z
dc.abstract.enPurpose Selected cell-cycle regulators and extracellular matrix proteins were found to play roles in malignant peripheral nerve sheath tumor (MPNST) biology. We aimed to analyze whether initial tumor tissue expressions of survivin, p53, cyclin D1, osteopontin (OPN) and fibronectin (FN) correlate with the response to neo-adjuvant CHT (naCHT) in children with advanced inoperable MPNST. Methods The study included 26 children with MPNST (M/F 14/12, median age 130 months) treated in Polish centers of pediatric oncology between 1992 and 2013. Tissue expression of markers was studied immunohistochemically in the manually performed tissue microarrays and assessed semi-quantitatively as low and high, based on the rate of positive cells and staining intensity. Results Good response to naCHT was noted in 47.6%, while poor-in 52.4% of patients. The response to naCHT was influenced negatively by the presence of neurofibromatosis NF1 and high initial tumor tissue expression of OPN, survivin, p53 and cyclin D1. Patients with high tumor expression of either OPN, survivin or p53 and those with simultaneous high expression of ≥ 3 of the markers, responded significantly worse to naCHT, than patients, in whom expression of ≤ 2 markers were detected at diagnosis. Nearly, 85% of patients expressing ≥ 3 markers, responded poor to CHT; while 87.5% of children, expressing ≤ 2 markers, were good responders. Conclusion The initial tumor tissue expression of OPN, survivin, p53 and cyclin D1 may serve as markers to predict response to naCHT in pediatric advanced MPNST. Future studies in more numerous group of patients are needed to confirm these preliminary results.pl
dc.affiliationWydział Lekarski : Instytut Pediatriipl
dc.cm.date2020-01-07
dc.cm.id87178
dc.contributor.authorKarpinsky, Gabriellepl
dc.contributor.authorKrawczyk, Małgorzata A.pl
dc.contributor.authorIzycka.Swieszewska, Ewapl
dc.contributor.authorFatyga, Aleksandrapl
dc.contributor.authorBudka, Agnieszkapl
dc.contributor.authorBalwierz, Walentyna - 128644 pl
dc.contributor.authorSobol, Grażynapl
dc.contributor.authorZalewska-Szewczyk, Beatapl
dc.contributor.authorRychłowska-Pruszyńska, Magdalenapl
dc.contributor.authorKlepacka, Teresapl
dc.contributor.authorDembowska-Bagińska, Bożennapl
dc.contributor.authorKazanowska, Bernardapl
dc.contributor.authorGabrych, Annapl
dc.contributor.authorBień, Ewapl
dc.date.accessioned2020-01-17T09:20:31Z
dc.date.available2020-01-17T09:20:31Z
dc.date.issued2018pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number3pl
dc.description.physical519-529pl
dc.description.points25pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume144pl
dc.identifier.doi10.1007/s00432-018-2580-1pl
dc.identifier.eissn1432-1335pl
dc.identifier.issn0171-5216pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/142406
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcode.pl*
dc.share.typeinne
dc.subject.ensurvivinpl
dc.subject.enp53pl
dc.subject.encyclin D1pl
dc.subject.enosteopontinpl
dc.subject.enresponse to neo-adjuvant chemotherapypl
dc.subject.enmalignant peripheral nerve sheath tumorpl
dc.subject.enchildrenpl
dc.subtypeArticlepl
dc.titleTumor expression of survivin, p53, cyclin D1, osteopontin and fibronectin in predicting the response to neo-adjuvant chemotherapy in children with advanced malignant peripheral nerve sheath tumorpl
dc.title.journalJournal of Cancer Research and Clinical Oncologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-09T21:58:49Z
dc.abstract.enpl
Purpose Selected cell-cycle regulators and extracellular matrix proteins were found to play roles in malignant peripheral nerve sheath tumor (MPNST) biology. We aimed to analyze whether initial tumor tissue expressions of survivin, p53, cyclin D1, osteopontin (OPN) and fibronectin (FN) correlate with the response to neo-adjuvant CHT (naCHT) in children with advanced inoperable MPNST. Methods The study included 26 children with MPNST (M/F 14/12, median age 130 months) treated in Polish centers of pediatric oncology between 1992 and 2013. Tissue expression of markers was studied immunohistochemically in the manually performed tissue microarrays and assessed semi-quantitatively as low and high, based on the rate of positive cells and staining intensity. Results Good response to naCHT was noted in 47.6%, while poor-in 52.4% of patients. The response to naCHT was influenced negatively by the presence of neurofibromatosis NF1 and high initial tumor tissue expression of OPN, survivin, p53 and cyclin D1. Patients with high tumor expression of either OPN, survivin or p53 and those with simultaneous high expression of ≥ 3 of the markers, responded significantly worse to naCHT, than patients, in whom expression of ≤ 2 markers were detected at diagnosis. Nearly, 85% of patients expressing ≥ 3 markers, responded poor to CHT; while 87.5% of children, expressing ≤ 2 markers, were good responders. Conclusion The initial tumor tissue expression of OPN, survivin, p53 and cyclin D1 may serve as markers to predict response to naCHT in pediatric advanced MPNST. Future studies in more numerous group of patients are needed to confirm these preliminary results.
dc.affiliationpl
Wydział Lekarski : Instytut Pediatrii
dc.cm.date
2020-01-07
dc.cm.id
87178
dc.contributor.authorpl
Karpinsky, Gabrielle
dc.contributor.authorpl
Krawczyk, Małgorzata A.
dc.contributor.authorpl
Izycka.Swieszewska, Ewa
dc.contributor.authorpl
Fatyga, Aleksandra
dc.contributor.authorpl
Budka, Agnieszka
dc.contributor.authorpl
Balwierz, Walentyna - 128644
dc.contributor.authorpl
Sobol, Grażyna
dc.contributor.authorpl
Zalewska-Szewczyk, Beata
dc.contributor.authorpl
Rychłowska-Pruszyńska, Magdalena
dc.contributor.authorpl
Klepacka, Teresa
dc.contributor.authorpl
Dembowska-Bagińska, Bożenna
dc.contributor.authorpl
Kazanowska, Bernarda
dc.contributor.authorpl
Gabrych, Anna
dc.contributor.authorpl
Bień, Ewa
dc.date.accessioned
2020-01-17T09:20:31Z
dc.date.available
2020-01-17T09:20:31Z
dc.date.issuedpl
2018
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
3
dc.description.physicalpl
519-529
dc.description.pointspl
25
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
144
dc.identifier.doipl
10.1007/s00432-018-2580-1
dc.identifier.eissnpl
1432-1335
dc.identifier.issnpl
0171-5216
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/142406
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl
dc.share.type
inne
dc.subject.enpl
survivin
dc.subject.enpl
p53
dc.subject.enpl
cyclin D1
dc.subject.enpl
osteopontin
dc.subject.enpl
response to neo-adjuvant chemotherapy
dc.subject.enpl
malignant peripheral nerve sheath tumor
dc.subject.enpl
children
dc.subtypepl
Article
dc.titlepl
Tumor expression of survivin, p53, cyclin D1, osteopontin and fibronectin in predicting the response to neo-adjuvant chemotherapy in children with advanced malignant peripheral nerve sheath tumor
dc.title.journalpl
Journal of Cancer Research and Clinical Oncology
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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