Endosonography-guided fine needle aspiration in the diagnosis of sarcoidosis : a randomized study

2017
journal article
article
15
dc.abstract.enThere are no widely accepted standards for the diagnosis of sarcoidosis. The aim of this study was to assess the relative diagnostic yield of endobronchial ultrasound fine-needle aspiration (EBUS‑FNA) and endoscopic ultrasound fine-needle aspiration (EUS‑FNA), and to compare them with standard diagnostic techniques such as endobronchial biopsy (EBB), transbronchial lung biopsy (TBLB), transbronchial needle aspiration (TBNA), and mediastinoscopy. This was a prospective randomized study including consecutive patients with clinical diagnosis of stage I or II sarcoidosis. EBB, TBLB, and TBNA were performed at baseline in all patients. Subsequently, patients were randomized to group A (EBUS‑FNA) or group B (EUS‑FNA). Next, a crossover control test was performed: all patients with negative results in group A underwent EUS‑FNA and all patients with negative results in group B underwent EBUS‑FNA. If sarcoidosis was not confirmed, mediastinoscopy was performed. We enrolled 106 patients, of whom 100 were available for the final analysis. The overall sensitivity and accuracy of standard endoscopic methods were 64% each. When analyzing each of the standard endoscopic methods separately, the diagnosis was confirmed with EBB in 12 patients (12%), with TBLB in 42 patients (42%), and with TBNA in 44 patients (44%). The sensitivity and accuracy of each endosonographic technique were significantly higher than those of EBB+TBLB+TBNA (P = 0.0112 vs P = 0.0134). The sensitivity and accuracy of EBUS‑FNA and EUS‑FNA are significantly higher than those of standard endoscopic methods. Moreover, the sensitivity and accuracy of EUS‑FNA tend to be higher than those of EBUS‑FNA.pl
dc.affiliationWydział Lekarski : Klinika Pulmonologiipl
dc.affiliationWydział Lekarski : Zakład Patomorfologii Klinicznej i Doświadczalnejpl
dc.affiliationWydział Nauk o Zdrowiu : Instytut Fizjoterapiipl
dc.cm.date2020-01-07
dc.cm.id83242
dc.contributor.authorKocoń, Piotr - 255991 pl
dc.contributor.authorSzlubowski, Arturpl
dc.contributor.authorKużdżał, Jarosław - 199984 pl
dc.contributor.authorRudnicka-Sosin, Lucynapl
dc.contributor.authorĆmiel, Adampl
dc.contributor.authorSoja, Jerzy - 133448 pl
dc.contributor.authorWłodarczyk, Janusz - 200008 pl
dc.contributor.authorTalar, Piotrpl
dc.contributor.authorSmęder, Tomaszpl
dc.contributor.authorGil, Tomasz - 200745 pl
dc.contributor.authorWarmus, Januszpl
dc.contributor.authorTomaszewska, Romana - 133668 pl
dc.date.accessioned2020-01-17T09:16:36Z
dc.date.available2020-01-17T09:16:36Z
dc.date.issued2017pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number3pl
dc.description.physical154-162pl
dc.description.points30pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume127pl
dc.identifier.doi10.20452/pamw.3934pl
dc.identifier.eissn1897-9483pl
dc.identifier.issn0032-3772pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/140816
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa*
dc.rights.licenceOTHER
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl*
dc.share.typeotwarte czasopismo
dc.subject.enbronchoscopypl
dc.subject.enendosonographpl
dc.subject.enmediastinoscopypl
dc.subject.ensarcoidosispl
dc.subtypeArticlepl
dc.titleEndosonography-guided fine needle aspiration in the diagnosis of sarcoidosis : a randomized studypl
dc.title.journalPolskie Archiwum Medycyny Wewnętrznej = Polish Archives of Internal Medicinepl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
There are no widely accepted standards for the diagnosis of sarcoidosis. The aim of this study was to assess the relative diagnostic yield of endobronchial ultrasound fine-needle aspiration (EBUS‑FNA) and endoscopic ultrasound fine-needle aspiration (EUS‑FNA), and to compare them with standard diagnostic techniques such as endobronchial biopsy (EBB), transbronchial lung biopsy (TBLB), transbronchial needle aspiration (TBNA), and mediastinoscopy. This was a prospective randomized study including consecutive patients with clinical diagnosis of stage I or II sarcoidosis. EBB, TBLB, and TBNA were performed at baseline in all patients. Subsequently, patients were randomized to group A (EBUS‑FNA) or group B (EUS‑FNA). Next, a crossover control test was performed: all patients with negative results in group A underwent EUS‑FNA and all patients with negative results in group B underwent EBUS‑FNA. If sarcoidosis was not confirmed, mediastinoscopy was performed. We enrolled 106 patients, of whom 100 were available for the final analysis. The overall sensitivity and accuracy of standard endoscopic methods were 64% each. When analyzing each of the standard endoscopic methods separately, the diagnosis was confirmed with EBB in 12 patients (12%), with TBLB in 42 patients (42%), and with TBNA in 44 patients (44%). The sensitivity and accuracy of each endosonographic technique were significantly higher than those of EBB+TBLB+TBNA (P = 0.0112 vs P = 0.0134). The sensitivity and accuracy of EBUS‑FNA and EUS‑FNA are significantly higher than those of standard endoscopic methods. Moreover, the sensitivity and accuracy of EUS‑FNA tend to be higher than those of EBUS‑FNA.
dc.affiliationpl
Wydział Lekarski : Klinika Pulmonologii
dc.affiliationpl
Wydział Lekarski : Zakład Patomorfologii Klinicznej i Doświadczalnej
dc.affiliationpl
Wydział Nauk o Zdrowiu : Instytut Fizjoterapii
dc.cm.date
2020-01-07
dc.cm.id
83242
dc.contributor.authorpl
Kocoń, Piotr - 255991
dc.contributor.authorpl
Szlubowski, Artur
dc.contributor.authorpl
Kużdżał, Jarosław - 199984
dc.contributor.authorpl
Rudnicka-Sosin, Lucyna
dc.contributor.authorpl
Ćmiel, Adam
dc.contributor.authorpl
Soja, Jerzy - 133448
dc.contributor.authorpl
Włodarczyk, Janusz - 200008
dc.contributor.authorpl
Talar, Piotr
dc.contributor.authorpl
Smęder, Tomasz
dc.contributor.authorpl
Gil, Tomasz - 200745
dc.contributor.authorpl
Warmus, Janusz
dc.contributor.authorpl
Tomaszewska, Romana - 133668
dc.date.accessioned
2020-01-17T09:16:36Z
dc.date.available
2020-01-17T09:16:36Z
dc.date.issuedpl
2017
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
3
dc.description.physicalpl
154-162
dc.description.pointspl
30
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
127
dc.identifier.doipl
10.20452/pamw.3934
dc.identifier.eissnpl
1897-9483
dc.identifier.issnpl
0032-3772
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/140816
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
dc.rights.licence
OTHER
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl
dc.share.type
otwarte czasopismo
dc.subject.enpl
bronchoscopy
dc.subject.enpl
endosonograph
dc.subject.enpl
mediastinoscopy
dc.subject.enpl
sarcoidosis
dc.subtypepl
Article
dc.titlepl
Endosonography-guided fine needle aspiration in the diagnosis of sarcoidosis : a randomized study
dc.title.journalpl
Polskie Archiwum Medycyny Wewnętrznej = Polish Archives of Internal Medicine
dc.typepl
JournalArticle
dspace.entity.type
Publication

* The migration of download and view statistics prior to the date of April 8, 2024 is in progress.

Views
15
Views per month
Views per city
Ashburn
3
Chandler
2
Wroclaw
2
Des Moines
1
Dublin
1
Namdong-gu
1
Downloads
kocon_et-al_fine_needle_aspiration_2017.pdf
9
kocon_et-al_fine_needle_aspiration_2017.odt
1