Profil aminokwasowy osocza krwi chłopców z autyzmem

2017
journal article
article
18
cris.lastimport.wos2024-04-10T01:15:37Z
dc.abstract.enThe aim of the study: It has been suggested that some amino acids are involved in the pathogenesis of autistic disorders. The aim of the study was to evaluate the plasma amino acids profile in young males with autism. Method: Total of 27 autistic boys (aged 2–10 years, the study group) without any metabolic disorders and 13 healthy boys (aged 2–9 years, control group) were included in the study. In all subjects fasting blood plasma free amino acids (both exogenous and endogenous) were quantitatively measured by high performance liquid chromatography with UV-VIS detection. Results: The mean plasma concentration values of citrulline, α-aminobutyric acid, isoleucine, leucine, phenylalanine, tryptophan and ornithine were significantly lower in boys with autism as compared to the control group (p < 0.03, p < 0.04, p < 0.02, p < 0.02, p < 0.05, p < 0.02, p < 0.05, respectively). The areas under the Receiver Operating Characteristic curves for these amino acids ranged from 0.637 to 0.726. None of the amino acids measured differentiate autistic children from healthy children. The sum of exogenous amino acids was lower in the study group than in the control group but this difference was not statistically significant. Conclusions: Lower levels of exogenous amino acids confirm the possible role of these amino acids in autism. Determination of exogenous amino acids in plasma, however, cannot be used as a diagnostic test but it can still support autistic patients care.pl
dc.affiliationWydział Lekarski : Instytut Pediatriipl
dc.cm.date2020-01-07
dc.cm.id81972
dc.contributor.authorBugajska, Jolanta - 128914 pl
dc.contributor.authorBerska, Joanna - 173905 pl
dc.contributor.authorWojtyto, Tomaszpl
dc.contributor.authorBik-Multanowski, Mirosław - 128777 pl
dc.contributor.authorSztefko, Krystyna - 133601 pl
dc.date.accessioned2020-01-17T09:15:35Z
dc.date.available2020-01-17T09:15:35Z
dc.date.issued2017pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number2pl
dc.description.physical359-368pl
dc.description.points15pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume51pl
dc.identifier.doi10.12740/PP/65046pl
dc.identifier.eissn2391-5854pl
dc.identifier.issn0033-2674pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/140426
dc.languagepolpl
dc.language.containerpolpl
dc.rightsUdzielam licencji. Uznanie autorstwa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses*
dc.share.typeotwarte czasopismo
dc.subject.enautismpl
dc.subject.enamino acidspl
dc.subject.enboyspl
dc.subject.plautyzmpl
dc.subject.plaminokwasypl
dc.subject.plchłopcypl
dc.subtypeArticlepl
dc.titleProfil aminokwasowy osocza krwi chłopców z autyzmempl
dc.title.alternativeThe amino acid profile in blood plasma of young boys with autismpl
dc.title.journalPsychiatria Polskapl
dc.typeJournalArticlepl
dspace.entity.typePublication
cris.lastimport.wos
2024-04-10T01:15:37Z
dc.abstract.enpl
The aim of the study: It has been suggested that some amino acids are involved in the pathogenesis of autistic disorders. The aim of the study was to evaluate the plasma amino acids profile in young males with autism. Method: Total of 27 autistic boys (aged 2–10 years, the study group) without any metabolic disorders and 13 healthy boys (aged 2–9 years, control group) were included in the study. In all subjects fasting blood plasma free amino acids (both exogenous and endogenous) were quantitatively measured by high performance liquid chromatography with UV-VIS detection. Results: The mean plasma concentration values of citrulline, α-aminobutyric acid, isoleucine, leucine, phenylalanine, tryptophan and ornithine were significantly lower in boys with autism as compared to the control group (p < 0.03, p < 0.04, p < 0.02, p < 0.02, p < 0.05, p < 0.02, p < 0.05, respectively). The areas under the Receiver Operating Characteristic curves for these amino acids ranged from 0.637 to 0.726. None of the amino acids measured differentiate autistic children from healthy children. The sum of exogenous amino acids was lower in the study group than in the control group but this difference was not statistically significant. Conclusions: Lower levels of exogenous amino acids confirm the possible role of these amino acids in autism. Determination of exogenous amino acids in plasma, however, cannot be used as a diagnostic test but it can still support autistic patients care.
dc.affiliationpl
Wydział Lekarski : Instytut Pediatrii
dc.cm.date
2020-01-07
dc.cm.id
81972
dc.contributor.authorpl
Bugajska, Jolanta - 128914
dc.contributor.authorpl
Berska, Joanna - 173905
dc.contributor.authorpl
Wojtyto, Tomasz
dc.contributor.authorpl
Bik-Multanowski, Mirosław - 128777
dc.contributor.authorpl
Sztefko, Krystyna - 133601
dc.date.accessioned
2020-01-17T09:15:35Z
dc.date.available
2020-01-17T09:15:35Z
dc.date.issuedpl
2017
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
2
dc.description.physicalpl
359-368
dc.description.pointspl
15
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
51
dc.identifier.doipl
10.12740/PP/65046
dc.identifier.eissnpl
2391-5854
dc.identifier.issnpl
0033-2674
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/140426
dc.languagepl
pol
dc.language.containerpl
pol
dc.rights*
Udzielam licencji. Uznanie autorstwa
dc.rights.licence
CC-BY
dc.rights.uri*
http://creativecommons.org/licenses
dc.share.type
otwarte czasopismo
dc.subject.enpl
autism
dc.subject.enpl
amino acids
dc.subject.enpl
boys
dc.subject.plpl
autyzm
dc.subject.plpl
aminokwasy
dc.subject.plpl
chłopcy
dc.subtypepl
Article
dc.titlepl
Profil aminokwasowy osocza krwi chłopców z autyzmem
dc.title.alternativepl
The amino acid profile in blood plasma of young boys with autism
dc.title.journalpl
Psychiatria Polska
dc.typepl
JournalArticle
dspace.entity.type
Publication

* The migration of download and view statistics prior to the date of April 8, 2024 is in progress.

Views
32
Views per month
Views per city
Ashburn
3
Dublin
3
Chandler
2
Krakow
2
Wroclaw
2
Bialystok
1
Des Moines
1
Gdynia
1
Golkowice Gorne
1
Poznan
1
Downloads
bugajska_et-al_profil_aminokwasowy_osocza_krwi_chlopcow_z_autyzmem_2017.pdf
4
bugajska_et-al_the_amino_acid_profile_in_blood_plasma_of_young_boys_with_autism_2017.pdf
4
bugajska_et-al_the_amino_acid_profile_in_blood_plasma_of_young_boys_with_autism_2017.odt
1
bugajska_et-al_profil_aminokwasowy_osocza_krwi_chlopcow_z_autyzmem_2017.odt
1