Structural role of hydrophobic core in proteins-selected examples

2016
journal article
article
cris.lastimport.wos2024-04-09T18:54:04Z
dc.abstract.enThis paper discusses the sequence/structure relation. The core question concerns the degree to which similar sequences produce similar structures and vice versa. A mechanism by which similar sequences may result in dissimilar structures is proposed, based on the Fuzzy Oil Drop (FOD) model in which structural similarity is estimated by analyzing the protein’s hydrophobic core. We show that local changes in amino acid sequences, in addition to producing local structural alterations at the substitution site, may also change the shape of the hydrophobic core, significantly affecting the overall tertiary conformation of the protein. Our analysis focuses on four sets of proteins: 1) Pair of designer proteins with specially prepared sequences; 2) Pair of natural proteins modified (mutated) to converge to a point of high-level sequence identity while retaining their respective wild-type tertiary folds; 3) Pair of natural proteins with common ancestry but with differing structures and biological profiles shaped by divergent evolution; and 4) Pair of natural proteins of high structural similarity with no sequence similarity and different biological function.pl
dc.affiliationWydział Lekarski : Zakład Bioinformatyki i Telemedycynypl
dc.cm.date2020-01-07
dc.cm.id79666
dc.contributor.authorBanach, Mateusz - 103003 pl
dc.contributor.authorKalinowska, B.pl
dc.contributor.authorKonieczny, Leszekpl
dc.contributor.authorRoterman-Konieczna, Irena - 133298 pl
dc.date.accessioned2020-01-17T09:10:36Z
dc.date.available2020-01-17T09:10:36Z
dc.date.issued2016pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number11pl
dc.description.physical276-286pl
dc.description.points5pl
dc.description.publication1,1pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume9pl
dc.identifier.doi10.4172/jpb.1000416pl
dc.identifier.eissn0974-276X
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/139013
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa*
dc.rights.licenceCC-BY
dc.rights.urihttp://creativecommons.org/licenses*
dc.share.typeotwarte czasopismo
dc.subject.enstructure comparisonpl
dc.subject.enstructure alignmentpl
dc.subject.enstructural differencespl
dc.subject.enstructure predictionpl
dc.subject.enevolutionpl
dc.subject.enprotein foldingpl
dc.subject.enhydrophobicitypl
dc.subtypeArticlepl
dc.titleStructural role of hydrophobic core in proteins-selected examplespl
dc.title.journalJournal of Proteomics and Bioinformaticspl
dc.typeJournalArticlepl
dspace.entity.typePublication
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