Carboxylated and undercarboxylated osteocalcin in metabolic complications of human obesity and prediabetes

2017
journal article
article
31
dc.abstract.enBackground Carboxylated osteocalcin (Gla‐OC) participates in bone remodeling, whereas the undercarboxylated form (Glu‐OC) takes part in energy metabolism. This study was undertaken to compare the blood levels of Glu‐OC and Gla‐OC in nonobese, healthy obese, and prediabetic volunteers and correlate it with the metabolic markers of insulin resistance and early markers of inflammation. Methods Nonobese (body mass index [BMI] <30 kg/m2 ; n = 34) and obese subjects (30 <BMI <40 kg/m2 ; n = 98), both sexes, aged 25 to 65 years, were divided into healthy control, normal weight subjects, healthy obese, and obese with biochemical markers of prediabetes. The subgroups with obesity and low or high Gla‐OC or Glu‐OC were also considered for statistical analysis. After 2 weeks of diet standardization, venous blood was sampled for the determination of Gla‐OC, Glu‐OC, lipid profile, parameters of inflammation (hsCRP, interleukin 6, sE‐selectin, sPECAM‐1, and monocyte chemoattractant protein 1), and adipokines (leptin, adiponectin, visfatin, and resistin). Results Gla‐OC in obese patients was significantly lower compared to nonobese ones (11.36 ± 0.39 vs 12.69 ± 0.90 ng/mL, P = .048) and weakly correlated with hsCRP (r = −0.18, P = .042), visfatin concentration (r = −0.19, P = .033), and BMI (r = −0.17, P = .047). Glu‐OC was negatively associated with fasting insulin levels (r = −0.18, P = .049) and reduced in prediabetic individuals compared with healthy obese volunteers (3.04 ± 0.28 vs 4.48 ± 0.57, P = .025). Conclusions Decreased blood concentration of Glu‐OC may be a selective early symptom of insulin resistance in obesity, whereas the decreased level of Gla‐OC seems to be associated with the appearance of early markers of low grade inflammation accompanying obesity.pl
dc.affiliationWydział Lekarski : Zakład Biochemii Klinicznejpl
dc.affiliationWydział Lekarski : Zakład Diagnostykipl
dc.affiliationWydział Lekarski : Klinika Chorób Metabolicznychpl
dc.affiliationWydział Lekarski : Zakład Diagnostyki Genetycznej i Nutrigenomikipl
dc.affiliationWydział Lekarski : Klinika Endokrynologiipl
dc.cm.date2020-01-07
dc.cm.id79278
dc.contributor.authorRaźny, Urszula - 133265 pl
dc.contributor.authorFedak, Danuta - 173913 pl
dc.contributor.authorKieć-Wilk, Beata - 130090 pl
dc.contributor.authorGóralska, Joanna - 129579 pl
dc.contributor.authorGruca, Anna - 129624 pl
dc.contributor.authorZdzienicka, Anna - 133912 pl
dc.contributor.authorKieć-Klimczak, Małgorzata - 159331 pl
dc.contributor.authorSolnica, Bogdan - 133453 pl
dc.contributor.authorHubalewska-Dydejczyk, Alicja - 129732 pl
dc.contributor.authorMalczewska-Malec, Małgorzata - 130821 pl
dc.date.accessioned2020-01-17T09:10:26Z
dc.date.available2020-01-17T09:10:26Z
dc.date.issued2017pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.number3pl
dc.description.points30pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume33pl
dc.identifier.articleide2862pl
dc.identifier.doi10.1002/dmrr.2862pl
dc.identifier.eissn1520-7560
dc.identifier.issn1520-7552pl
dc.identifier.projectROD UJ / OPpl
dc.identifier.urihttps://ruj.uj.edu.pl/xmlui/handle/item/138767
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa*
dc.rights.licenceCC-BY-NC
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/legalcode.pl*
dc.share.typeinne
dc.subject.encarboxylated osteocalcinpl
dc.subject.enobesitypl
dc.subject.enprediabetespl
dc.subject.enundercarboxylated osteocalcinpl
dc.subtypeArticlepl
dc.titleCarboxylated and undercarboxylated osteocalcin in metabolic complications of human obesity and prediabetespl
dc.title.journalDiabetes/Metabolism Research and Reviewspl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
Background Carboxylated osteocalcin (Gla‐OC) participates in bone remodeling, whereas the undercarboxylated form (Glu‐OC) takes part in energy metabolism. This study was undertaken to compare the blood levels of Glu‐OC and Gla‐OC in nonobese, healthy obese, and prediabetic volunteers and correlate it with the metabolic markers of insulin resistance and early markers of inflammation. Methods Nonobese (body mass index [BMI] <30 kg/m2 ; n = 34) and obese subjects (30 <BMI <40 kg/m2 ; n = 98), both sexes, aged 25 to 65 years, were divided into healthy control, normal weight subjects, healthy obese, and obese with biochemical markers of prediabetes. The subgroups with obesity and low or high Gla‐OC or Glu‐OC were also considered for statistical analysis. After 2 weeks of diet standardization, venous blood was sampled for the determination of Gla‐OC, Glu‐OC, lipid profile, parameters of inflammation (hsCRP, interleukin 6, sE‐selectin, sPECAM‐1, and monocyte chemoattractant protein 1), and adipokines (leptin, adiponectin, visfatin, and resistin). Results Gla‐OC in obese patients was significantly lower compared to nonobese ones (11.36 ± 0.39 vs 12.69 ± 0.90 ng/mL, P = .048) and weakly correlated with hsCRP (r = −0.18, P = .042), visfatin concentration (r = −0.19, P = .033), and BMI (r = −0.17, P = .047). Glu‐OC was negatively associated with fasting insulin levels (r = −0.18, P = .049) and reduced in prediabetic individuals compared with healthy obese volunteers (3.04 ± 0.28 vs 4.48 ± 0.57, P = .025). Conclusions Decreased blood concentration of Glu‐OC may be a selective early symptom of insulin resistance in obesity, whereas the decreased level of Gla‐OC seems to be associated with the appearance of early markers of low grade inflammation accompanying obesity.
dc.affiliationpl
Wydział Lekarski : Zakład Biochemii Klinicznej
dc.affiliationpl
Wydział Lekarski : Zakład Diagnostyki
dc.affiliationpl
Wydział Lekarski : Klinika Chorób Metabolicznych
dc.affiliationpl
Wydział Lekarski : Zakład Diagnostyki Genetycznej i Nutrigenomiki
dc.affiliationpl
Wydział Lekarski : Klinika Endokrynologii
dc.cm.date
2020-01-07
dc.cm.id
79278
dc.contributor.authorpl
Raźny, Urszula - 133265
dc.contributor.authorpl
Fedak, Danuta - 173913
dc.contributor.authorpl
Kieć-Wilk, Beata - 130090
dc.contributor.authorpl
Góralska, Joanna - 129579
dc.contributor.authorpl
Gruca, Anna - 129624
dc.contributor.authorpl
Zdzienicka, Anna - 133912
dc.contributor.authorpl
Kieć-Klimczak, Małgorzata - 159331
dc.contributor.authorpl
Solnica, Bogdan - 133453
dc.contributor.authorpl
Hubalewska-Dydejczyk, Alicja - 129732
dc.contributor.authorpl
Malczewska-Malec, Małgorzata - 130821
dc.date.accessioned
2020-01-17T09:10:26Z
dc.date.available
2020-01-17T09:10:26Z
dc.date.issuedpl
2017
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.numberpl
3
dc.description.pointspl
30
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
33
dc.identifier.articleidpl
e2862
dc.identifier.doipl
10.1002/dmrr.2862
dc.identifier.eissn
1520-7560
dc.identifier.issnpl
1520-7552
dc.identifier.projectpl
ROD UJ / OP
dc.identifier.uri
https://ruj.uj.edu.pl/xmlui/handle/item/138767
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa
dc.rights.licence
CC-BY-NC
dc.rights.uri*
http://creativecommons.org/licenses/by-nc/4.0/legalcode.pl
dc.share.type
inne
dc.subject.enpl
carboxylated osteocalcin
dc.subject.enpl
obesity
dc.subject.enpl
prediabetes
dc.subject.enpl
undercarboxylated osteocalcin
dc.subtypepl
Article
dc.titlepl
Carboxylated and undercarboxylated osteocalcin in metabolic complications of human obesity and prediabetes
dc.title.journalpl
Diabetes/Metabolism Research and Reviews
dc.typepl
JournalArticle
dspace.entity.type
Publication

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