Design and synthesis of novel cannabinoid ligands based on a 1,2,3- triazole scaffold

2013
journal article
article
5
cris.lastimport.scopus2024-04-24T02:52:03Z
cris.lastimport.wos2024-04-09T20:20:00Z
dc.abstract.enFollowing "click chemistry" guidelines, a 1,2,3-triazole scaffold was introduced in place of a benzene ring to mimic the non-classical cannabinoid pharmacophore model in a novel class of compounds aimed at CB1 receptor agonism. The design, synthesis and results of receptor affinity tests for the new group of ligands are described. The obtained series exhibited a similar sidechainlength-activity relationship as in the initial pharmacophore model, with moderate CB1- selectivity.pl
dc.affiliationWydział Chemii : Zakład Chemii Organicznejpl
dc.cm.id61931
dc.contributor.authorSzafrański, Przemysław - 112720 pl
dc.contributor.authorDyduch, Karol - 107712 pl
dc.contributor.authorKościółek, Tomaszpl
dc.contributor.authorWróbel, Tomasz P. - 107687 pl
dc.contributor.authorGomez-Canas, Mariapl
dc.contributor.authorFernandez-Ruiz, Javierpl
dc.contributor.authorMłynarski, Jacek - 173385 pl
dc.contributor.authorGomes-Ruiz, Mariapl
dc.date.accessioned2015-06-19T10:58:18Z
dc.date.available2015-06-19T10:58:18Z
dc.date.issued2013pl
dc.description.number2pl
dc.description.physical169-172pl
dc.description.points15pl
dc.description.volume10pl
dc.identifier.doi10.2174/157018013804725134pl
dc.identifier.eissn1875-628Xpl
dc.identifier.issn1570-1808pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/9916
dc.languageengpl
dc.language.containerengpl
dc.rights.licencebez licencji
dc.subtypeArticlepl
dc.titleDesign and synthesis of novel cannabinoid ligands based on a 1,2,3- triazole scaffoldpl
dc.title.journalLetters in Drug Design & Discoverypl
dc.typeJournalArticlepl
dspace.entity.typePublication
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