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Design and synthesis of novel cannabinoid ligands based on a 1,2,3- triazole scaffold
Journal
Letters in Drug Design & Discovery
15
Author
Szafrański Przemysław
Dyduch Karol
Kościółek Tomasz
Wróbel Tomasz P.
Gomez-Canas Maria
Fernandez-Ruiz Javier
Młynarski Jacek
Gomes-Ruiz Maria
Volume
10
Issue
2
Pages
169-172
ISSN
1570-1808
eISSN
1875-628X
Language
English
Container language
English
Abstract in English
Following "click chemistry" guidelines, a 1,2,3-triazole scaffold was introduced in place of a benzene ring to mimic the non-classical cannabinoid pharmacophore model in a novel class of compounds aimed at CB1 receptor agonism. The design, synthesis and results of receptor affinity tests for the new group of ligands are described. The obtained series exhibited a similar sidechainlength-activity relationship as in the initial pharmacophore model, with moderate CB1- selectivity.
Affiliation
Wydział Chemii : Zakład Chemii Organicznej
Scopus© citations
5
cris.lastimport.scopus | 2024-04-24T02:52:03Z | |
cris.lastimport.wos | 2024-04-09T20:20:00Z | |
dc.abstract.en | Following "click chemistry" guidelines, a 1,2,3-triazole scaffold was introduced in place of a benzene ring to mimic the non-classical cannabinoid pharmacophore model in a novel class of compounds aimed at CB1 receptor agonism. The design, synthesis and results of receptor affinity tests for the new group of ligands are described. The obtained series exhibited a similar sidechainlength-activity relationship as in the initial pharmacophore model, with moderate CB1- selectivity. | pl |
dc.affiliation | Wydział Chemii : Zakład Chemii Organicznej | pl |
dc.cm.id | 61931 | |
dc.contributor.author | Szafrański, Przemysław - 112720 | pl |
dc.contributor.author | Dyduch, Karol - 107712 | pl |
dc.contributor.author | Kościółek, Tomasz | pl |
dc.contributor.author | Wróbel, Tomasz P. - 107687 | pl |
dc.contributor.author | Gomez-Canas, Maria | pl |
dc.contributor.author | Fernandez-Ruiz, Javier | pl |
dc.contributor.author | Młynarski, Jacek - 173385 | pl |
dc.contributor.author | Gomes-Ruiz, Maria | pl |
dc.date.accessioned | 2015-06-19T10:58:18Z | |
dc.date.available | 2015-06-19T10:58:18Z | |
dc.date.issued | 2013 | pl |
dc.description.number | 2 | pl |
dc.description.physical | 169-172 | pl |
dc.description.points | 15 | pl |
dc.description.volume | 10 | pl |
dc.identifier.doi | 10.2174/157018013804725134 | pl |
dc.identifier.eissn | 1875-628X | pl |
dc.identifier.issn | 1570-1808 | pl |
dc.identifier.uri | http://ruj.uj.edu.pl/xmlui/handle/item/9916 | |
dc.language | eng | pl |
dc.language.container | eng | pl |
dc.rights.licence | bez licencji | |
dc.subtype | Article | pl |
dc.title | Design and synthesis of novel cannabinoid ligands based on a 1,2,3- triazole scaffold | pl |
dc.title.journal | Letters in Drug Design & Discovery | pl |
dc.type | JournalArticle | pl |
dspace.entity.type | Publication |
Affiliations
Wydział Chemii
Młynarski, Jacek
Dyduch, Karol
Wróbel, Tomasz P.
Wydział Farmaceutyczny
Szafrański, Przemysław
No affiliation
Kościółek, Tomasz
Gomez-Canas, Maria
Fernandez-Ruiz, Javier
Gomes-Ruiz, Maria
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