We construct the first exact statistically homogeneous and isotropic cosmological solution in which inhomogeneity has a significant effect on the expansion rate. The universe is modelled as a Swiss Cheese, with dust FRW background and inhomogeneous holes. We show that if the holes are described by the quasispherical Szekeres solution, their average expansion rate is close to the background under certain rather general conditions. We specialise to spherically symmetric holes and violate one of these conditions. As a result, the average expansion rate at late times grows relative to the background, i.e. backreaction is significant. The holes fit smoothly into the background, but are larger on the inside than a corresponding background domain: we call them "Tardis regions". We study light propagation, find the effective equations of state and consider the relation of the spatially averaged expansion rate to the redshift and the angular diameter distance.