Four cores from 1200 m water depth from Vestnesa Ridge on the western Svalbard margin in the eastern Fram Strait were studied for their content of fossil macrofaunas. Three of the cores were collected from a pockmark with active methane seepage, and one core (control core) was taken just outside the seepage area for comparison. Together the cores cover the last 45 000 years (mid-late Weichselian glacial, the deglaciation and the Holocene). The records show a range of influence of methane from no seepage (control core) and, although variable through time, from moderate seepage, to strong and very strong seepage. All cores have been analysed for the macrofossils >1 mm, trace fossils, planktic foraminifera, stable isotopes, geochemistry and sedimentology. The main purpose of the study is to improve our knowledge of the fossil macrofauna and past environmental changes related to the impact of methane emissions in the area. The core recovered outside the pockmark contained no fossil macrofaunas, while cores from inside the pockmark contained chemosymbiotic bivalves, and in some cases a rich macrofauna. The faunal relationships with the sedimentary environments confirm a close connection between the macrofauna and the variability in influence of cold seepage, particularly seen in the occurrence of chemosymbiotic bivalves Archivesica arctica, Isorropodon nyeggaensis, potentially chemosymbiotic bivalve Rhacothyas kolgae, polychaetes and an associated rich fauna of small epifaunal gastropods, showing that Arctic seeps were oases for macrofaunas in the past as they are today.