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Affinity of alkylphosphocholines to biological membrane of prostate cancer : studies in natural and model systems
Journal
The Journal of Membrane Biology
Author
Wnętrzak Anita
Lipiec Ewelina
Łątka Kazimierz
Kwiatek Wojciech
Dynarowicz-Łątka Patrycja
Volume
247
Number
7
Pages
581-589
ISSN
0022-2631
eISSN
1432-1424
Keywords in English
alkylphosphocholines
model membrane
Langmuir monolayers
prostate cancer
Access date
2019-03-11
Language
English
Journal language
English
Abstract in English
The effectiveness of two alkylphosphocholines (APCs), hexadecylphosphocholine (miltefosine) and erucylphosphocholine to combat prostate cancer has been studied in vitro with artificial cancerous membrane, modelled with the Langmuir monolayer technique, and on cell line (Du-145). Studies performed with the Langmuir method indicate that both the investigated drugs have the affinity to the monolayer mimicking prostate cancer membrane (composed of cholesterol:POPC = 0.428) and the drug-membrane interactions are stronger for erucylphosphocholine as compared to hexadecylphosphocholine. Moreover, both studied drugs were found to fluidize the model membrane, which may lead to apoptosis. Indeed, biological studies confirmed that in Du-145 cell line both investigated alkylphosphocholines cause cell death primarily by apoptosis while necrotic cells constitute only a small percentage of APC-treated cells.
Affiliation
Wydział Chemii : Zakład Chemii OgólnejWydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego
Scopus© citations
14
| cris.lastimport.wos | 2024-04-10T02:11:09Z | |
| dc.abstract.en | The effectiveness of two alkylphosphocholines (APCs), hexadecylphosphocholine (miltefosine) and erucylphosphocholine to combat prostate cancer has been studied in vitro with artificial cancerous membrane, modelled with the Langmuir monolayer technique, and on cell line (Du-145). Studies performed with the Langmuir method indicate that both the investigated drugs have the affinity to the monolayer mimicking prostate cancer membrane (composed of cholesterol:POPC = 0.428) and the drug-membrane interactions are stronger for erucylphosphocholine as compared to hexadecylphosphocholine. Moreover, both studied drugs were found to fluidize the model membrane, which may lead to apoptosis. Indeed, biological studies confirmed that in Du-145 cell line both investigated alkylphosphocholines cause cell death primarily by apoptosis while necrotic cells constitute only a small percentage of APC-treated cells. | pl |
| dc.affiliation | Wydział Chemii : Zakład Chemii Ogólnej | pl |
| dc.affiliation | Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego | pl |
| dc.contributor.author | Wnętrzak, Anita - 157862 | pl |
| dc.contributor.author | Lipiec, Ewelina | pl |
| dc.contributor.author | Łątka, Kazimierz - 100050 | pl |
| dc.contributor.author | Kwiatek, Wojciech | pl |
| dc.contributor.author | Dynarowicz-Łątka, Patrycja - 127845 | pl |
| dc.date.accession | 2019-03-11 | pl |
| dc.date.accessioned | 2015-05-27T08:36:49Z | |
| dc.date.available | 2015-05-27T08:36:49Z | |
| dc.date.issued | 2014 | pl |
| dc.date.openaccess | 0 | |
| dc.description.accesstime | w momencie opublikowania | |
| dc.description.number | 7 | pl |
| dc.description.physical | 581-589 | pl |
| dc.description.publication | 0,5 | pl |
| dc.description.version | ostateczna wersja wydawcy | |
| dc.description.volume | 247 | pl |
| dc.identifier.doi | 10.1007/s00232-014-9674-8 | pl |
| dc.identifier.eissn | 1432-1424 | pl |
| dc.identifier.issn | 0022-2631 | pl |
| dc.identifier.project | ROD UJ / P | pl |
| dc.identifier.uri | http://ruj.uj.edu.pl/xmlui/handle/item/8181 | |
| dc.identifier.weblink | https://link.springer.com/content/pdf/10.1007%2Fs00232-014-9674-8.pdf | pl |
| dc.language | eng | pl |
| dc.language.container | eng | pl |
| dc.rights | Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa | * |
| dc.rights.licence | CC-BY | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/legalcode.pl | * |
| dc.share.type | inne | |
| dc.subject.en | alkylphosphocholines | pl |
| dc.subject.en | model membrane | pl |
| dc.subject.en | Langmuir monolayers | pl |
| dc.subject.en | prostate cancer | pl |
| dc.subtype | Article | pl |
| dc.title | Affinity of alkylphosphocholines to biological membrane of prostate cancer : studies in natural and model systems | pl |
| dc.title.journal | The Journal of Membrane Biology | pl |
| dc.type | JournalArticle | pl |
| dspace.entity.type | Publication |
cris.lastimport.wos
2024-04-10T02:11:09Z dc.abstract.enpl
The effectiveness of two alkylphosphocholines (APCs), hexadecylphosphocholine (miltefosine) and erucylphosphocholine to combat prostate cancer has been studied in vitro with artificial cancerous membrane, modelled with the Langmuir monolayer technique, and on cell line (Du-145). Studies performed with the Langmuir method indicate that both the investigated drugs have the affinity to the monolayer mimicking prostate cancer membrane (composed of cholesterol:POPC = 0.428) and the drug-membrane interactions are stronger for erucylphosphocholine as compared to hexadecylphosphocholine. Moreover, both studied drugs were found to fluidize the model membrane, which may lead to apoptosis. Indeed, biological studies confirmed that in Du-145 cell line both investigated alkylphosphocholines cause cell death primarily by apoptosis while necrotic cells constitute only a small percentage of APC-treated cells. dc.affiliationpl
Wydział Chemii : Zakład Chemii Ogólnej dc.affiliationpl
Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego dc.contributor.authorpl
Wnętrzak, Anita - 157862 dc.contributor.authorpl
Lipiec, Ewelina dc.contributor.authorpl
Łątka, Kazimierz - 100050 dc.contributor.authorpl
Kwiatek, Wojciech dc.contributor.authorpl
Dynarowicz-Łątka, Patrycja - 127845 dc.date.accessionpl
2019-03-11 dc.date.accessioned
2015-05-27T08:36:49Z dc.date.available
2015-05-27T08:36:49Z dc.date.issuedpl
2014 dc.date.openaccess
0 dc.description.accesstime
w momencie opublikowania dc.description.numberpl
7 dc.description.physicalpl
581-589 dc.description.publicationpl
0,5 dc.description.version
ostateczna wersja wydawcy dc.description.volumepl
247 dc.identifier.doipl
10.1007/s00232-014-9674-8 dc.identifier.eissnpl
1432-1424 dc.identifier.issnpl
0022-2631 dc.identifier.projectpl
ROD UJ / P dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/8181 dc.identifier.weblinkpl
https://link.springer.com/content/pdf/10.1007%2Fs00232-014-9674-8.pdf dc.languagepl
eng dc.language.containerpl
eng dc.rights*
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa dc.rights.licence
CC-BY dc.rights.uri*
http://creativecommons.org/licenses/by/4.0/legalcode.pl dc.share.type
inne dc.subject.enpl
alkylphosphocholines dc.subject.enpl
model membrane dc.subject.enpl
Langmuir monolayers dc.subject.enpl
prostate cancer dc.subtypepl
Article dc.titlepl
Affinity of alkylphosphocholines to biological membrane of prostate cancer : studies in natural and model systems dc.title.journalpl
The Journal of Membrane Biology dc.typepl
JournalArticle dspace.entity.type
Publication Affiliations
Wydział Fizyki, Astronomii i Informatyki Stosowanej
Wnętrzak, Anita
Łątka, Kazimierz
Wydział Chemii
Dynarowicz-Łątka, Patrycja
No affiliation
Lipiec, Ewelina
Kwiatek, Wojciech
* The migration of download and view statistics prior to the date of April 8, 2024 is in progress.
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