The purpose of this article was to introduce the possible future relations between China and the United States of America under Donald Trump’s presidency. The paper is divided into five sections: economy, real challenges, trade policy and industry, diplomacy. Each of them is introducing key issues in terms of the main topic. The secondary point of this article was to show the gravity of change after United States of America election results in December 2016 and the impact of this event on American policy toward China. The main conclusion which arised from the article is: USA-China relations during upcoming decade are going to be eminently tensed that it was before. Trade policy, Taiwan, strategic rapprochement of the United States of America with such countries as India and Russia, as well as innovation race across many industries, will remain a point of contention. The future of Sino-US relations will probably depend mostly on the emerging administration of the 45th President of the United States of America.