The aim of the study was to find out whether and how personality and demographic factors interact in shaping the relationship between work and family in the local government employees. The participants (N=100) were male (33) and female (67) workers of a local government office aged between 26 and 66 years (M=45.0 years; SD=10.4 years). Work-family interface was assessed using Work-Family Spillover Scale and personality traits were measured by NEO-Five Factor Inventory. Multivariate regression analyses (stepwise method) and bivariate correlation analyses were applied in order to find out the determinants of the work-family interface. The results have shown that work- family relationship was determined by both personality and demographic variables and their interactions (weak or moderate fit). Work-family conflict was explained by openness to experience (negative relationship) and positive interaction of neuroticism and having small children, and age and sex (weak fit of the model). Family-work conflict was explained (moderately) by agreeableness (negative), interaction of neuroticism and having small children (positive) and conscientiousness (negative). Work-family facilitation was determined (weak fit) by interactions of sex, having small children, neuroticism and agreeableness and separately by conscientiousness. Family-work facilitation was determined (moderate fit) by extraversion (positive) and interactions of sex and agreeableness (negative in females) and conscientiousness (positive in males). The results showed that in the population of local government workers dominated by women in early and middle adulthood, the relationships between work and family were determined by interaction of personality and demographic variables.