Changes in the nitric oxide level in the rat liver as a response to brain injury

2011
journal article
article
5
dc.abstract.otherLiver disturbances stimulate inflammatory reaction in the brain but little is known if injury to the brain can significantly influence liver metabolism. This problem is crucial in modern transplantology, as the condition of the donor brain seems to strongly affect the quality (viability) of the graft, which is often obtained from brain-dead donors, usually after traumatic brain injury. Because nitric oxide is one of the significant molecules in brain and liver biology, we examined if brain injury can affect NO level in the liver. Liver samples of Wistar rats were collected and studied with EPR NO-metry to detect NO level changes at different time points after brain injury. Shortly after the trauma, NO level in the liver was similar to the control. However, later there was a significant increase in the NO content in the livers starting from the 2nd day after brain injury and lasting up to the 7th day. It seems that the response to a mechanical brain injury is of the systemic, rather than local character. Therefore brain metabolism disturbances can influence liver metabolism at least by stimulating the organ to produce NO.pl
dc.affiliationWydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizykipl
dc.affiliationWydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki Molekularnejpl
dc.contributor.authorZiaja, Marek - 132904 pl
dc.contributor.authorPyka, Janusz - 131594 pl
dc.contributor.authorBoczkuś, Bożenapl
dc.contributor.authorPłonka, Beata - 131458 pl
dc.contributor.authorPłonka, Przemysław - 131459 pl
dc.date.accessioned2016-09-26T12:36:38Z
dc.date.available2016-09-26T12:36:38Z
dc.date.issued2011pl
dc.description.number4pl
dc.description.physical423-430pl
dc.description.volume25pl
dc.identifier.doi10.1016/j.niox.2011.07.004pl
dc.identifier.eissn1089-8611pl
dc.identifier.issn1089-8603pl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/30767
dc.languageengpl
dc.language.containerengpl
dc.rightsDodaję tylko opis bibliograficzny*
dc.rights.licenceBez licencji otwartego dostępu
dc.rights.uri*
dc.subtypeArticlepl
dc.titleChanges in the nitric oxide level in the rat liver as a response to brain injurypl
dc.title.journalNitric Oxidepl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.otherpl
Liver disturbances stimulate inflammatory reaction in the brain but little is known if injury to the brain can significantly influence liver metabolism. This problem is crucial in modern transplantology, as the condition of the donor brain seems to strongly affect the quality (viability) of the graft, which is often obtained from brain-dead donors, usually after traumatic brain injury. Because nitric oxide is one of the significant molecules in brain and liver biology, we examined if brain injury can affect NO level in the liver. Liver samples of Wistar rats were collected and studied with EPR NO-metry to detect NO level changes at different time points after brain injury. Shortly after the trauma, NO level in the liver was similar to the control. However, later there was a significant increase in the NO content in the livers starting from the 2nd day after brain injury and lasting up to the 7th day. It seems that the response to a mechanical brain injury is of the systemic, rather than local character. Therefore brain metabolism disturbances can influence liver metabolism at least by stimulating the organ to produce NO.
dc.affiliationpl
Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki
dc.affiliationpl
Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki Molekularnej
dc.contributor.authorpl
Ziaja, Marek - 132904
dc.contributor.authorpl
Pyka, Janusz - 131594
dc.contributor.authorpl
Boczkuś, Bożena
dc.contributor.authorpl
Płonka, Beata - 131458
dc.contributor.authorpl
Płonka, Przemysław - 131459
dc.date.accessioned
2016-09-26T12:36:38Z
dc.date.available
2016-09-26T12:36:38Z
dc.date.issuedpl
2011
dc.description.numberpl
4
dc.description.physicalpl
423-430
dc.description.volumepl
25
dc.identifier.doipl
10.1016/j.niox.2011.07.004
dc.identifier.eissnpl
1089-8611
dc.identifier.issnpl
1089-8603
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/30767
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Dodaję tylko opis bibliograficzny
dc.rights.licence
Bez licencji otwartego dostępu
dc.rights.uri*
dc.subtypepl
Article
dc.titlepl
Changes in the nitric oxide level in the rat liver as a response to brain injury
dc.title.journalpl
Nitric Oxide
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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