dc.contributor.author |
Maślak, Edyta [SAP14006481] |
pl |
dc.contributor.author |
Buczek, Elżbieta [SAP14004670] |
pl |
dc.contributor.author |
Szumny, Antoni |
pl |
dc.contributor.author |
Szczepański, Wojciech [SAP20000726] |
pl |
dc.contributor.author |
Franczyk-Żarów, Magdalena |
pl |
dc.contributor.author |
Kopec, Aneta |
pl |
dc.contributor.author |
Chłopicki, Stefan [SAP20000969] |
pl |
dc.contributor.author |
Leszczynska, Teresa |
pl |
dc.contributor.author |
Kostogrys, Renata B. [SAP20011854] |
pl |
dc.date.accessioned |
2016-08-24T07:10:30Z |
|
dc.date.available |
2016-08-24T07:10:30Z |
|
dc.date.issued |
2015 |
pl |
dc.identifier.issn |
2314-6133 |
pl |
dc.identifier.uri |
http://ruj.uj.edu.pl/xmlui/handle/item/29813 |
|
dc.language |
eng |
pl |
dc.rights |
Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa |
* |
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/legalcode.pl |
* |
dc.rights.uri |
Molecular Mechanisms of NAFLD in Metabolic Syndrome |
pl |
dc.title |
Individual CLA isomers, c9t11 and t10c12, prevent excess liver glycogen storage and inhibit lipogenic genes expression induced by high-fructose diet in rats |
pl |
dc.type |
JournalArticle |
pl |
dc.abstract.en |
This study assessed the effects of individual conjugated linoleic acid isomers, c9t11-CLA and t10c12-CLA, on nonalcoholic fatty liver disease (NAFLD) and systemic endothelial dysfunction in rats fed for four weeks with control or high-fructose diet. The high-fructose diet hampered body weight gain (without influencing food intake), increased liver weight and glycogen storage in hepatocytes, upregulated expression of fatty acid synthase (FAS) and stearoyl-CoA desaturase-1 (SCD-1), and increased saturated fatty acid (SFA) content in the liver. Both CLA isomers prevented excessive accumulation of glycogen in the liver. Specifically, t10c12-CLA decreased concentration of serum triacylglycerols and LDL + VLDL cholesterol, increased HDL cholesterol, and affected liver lipid content and fatty acid composition by downregulation of liver SCD-1 and FAS expression. In turn, the c9t11-CLA decreased LDL+VLDL cholesterol in the control group and downregulated liver expression of FAS without significant effects on liver weight, lipid content, and fatty acid composition. In summary, feeding rats with a high-fructose diet resulted in increased liver glycogen storage, indicating the induction of gluconeogenesis despite simultaneous upregulation of genes involved in de novo lipogenesis. Although both CLA isomers (c9t11 and t10c12) display hepatoprotective activity, the hypolipemic action of the t10c12-CLA isomer proved to be more pronounced than that of c9t11-CLA. |
pl |
dc.subject.en |
acyl coenzyme A desaturase |
pl |
dc.subject.en |
c9t11 conjugated linoleic acid |
pl |
dc.subject.en |
conjugated linoleic acid |
pl |
dc.subject.en |
fatty acid synthase |
pl |
dc.subject.en |
fructose |
pl |
dc.subject.en |
glycogen |
pl |
dc.subject.en |
high density lipoprotein cholesterol |
pl |
dc.subject.en |
low density lipoprotein cholesterol |
pl |
dc.subject.en |
monounsaturated fatty acid |
pl |
dc.subject.en |
n(g) nitroarginine methyl ester |
pl |
dc.subject.en |
polyunsaturated fatty acid |
pl |
dc.subject.en |
saturated fatty acid |
pl |
dc.subject.en |
t10cl2 conjugated linoleic acid |
pl |
dc.subject.en |
triacylglycerol |
pl |
dc.subject.en |
unclassified drug |
pl |
dc.subject.en |
very low density lipoprotein cholesterol |
pl |
dc.subject.en |
animal experiment |
pl |
dc.subject.en |
animal model |
pl |
dc.subject.en |
animal tissue |
pl |
dc.subject.en |
article |
pl |
dc.subject.en |
blood biochemistry |
pl |
dc.subject.en |
body weight |
pl |
dc.subject.en |
cholesterol blood level |
pl |
dc.subject.en |
comparative study |
pl |
dc.subject.en |
control |
pl |
dc.subject.en |
controlled study |
pl |
dc.subject.en |
down regulation |
pl |
dc.subject.en |
endothelial dysfunction |
pl |
dc.subject.en |
fat content |
pl |
dc.subject.en |
food intake |
pl |
dc.subject.en |
gene expression |
pl |
dc.subject.en |
gluconeogenesis |
pl |
dc.subject.en |
glycogen analysis |
pl |
dc.subject.en |
glycogen liver level |
pl |
dc.subject.en |
histopathology |
pl |
dc.subject.en |
isomer |
pl |
dc.subject.en |
lipid blood level |
pl |
dc.subject.en |
lipid composition |
pl |
dc.subject.en |
lipid liver level |
pl |
dc.subject.en |
liver cell |
pl |
dc.subject.en |
liver weight |
pl |
dc.subject.en |
male |
pl |
dc.subject.en |
nonalcoholic fatty liver |
pl |
dc.subject.en |
nonhuman |
pl |
dc.subject.en |
rat |
pl |
dc.subject.en |
real time polymerase chain reaction |
pl |
dc.subject.en |
reverse transcription polymerase chain reaction |
pl |
dc.subject.en |
triacylglycerol blood level |
pl |
dc.subject.en |
upregulation |
pl |
dc.subject.en |
vasodilatation |
pl |
dc.subject.en |
weight gain |
pl |
dc.subject.en |
Rattus |
pl |
dc.description.volume |
2015 |
pl |
dc.description.number |
Special Issue |
pl |
dc.description.points |
20 |
pl |
dc.identifier.doi |
10.1155/2015/535982 |
pl |
dc.identifier.eissn |
2314-6141 |
pl |
dc.title.journal |
BioMed Research International |
pl |
dc.title.volume |
Molecular Mechanisms of NAFLD in Metabolic Syndrome |
pl |
dc.language.container |
eng |
pl |
dc.affiliation |
Pion Rektora : Jagiellońskie Centrum Rozwoju Leków |
pl |
dc.affiliation |
Wydział Lekarski : Zakład Farmakologii |
pl |
dc.affiliation |
Wydział Lekarski : Zakład Patomorfologii Klinicznej i Doświadczalnej |
pl |
dc.subtype |
Article |
pl |
dc.identifier.articleid |
535982 |
pl |
dc.rights.original |
CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; |
pl |
dc.identifier.project |
ROD UJ / P |
pl |
dc.cm.id |
73240 |
|
.pointsMNiSW |
[2015 A]: 20 |
|