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Kinetic and thermodynamic studies of moxifloxacin hydrolysis in the presence and absence of metal ions in acidic solutions
fluoroquinolones
1H NMR
LC-MS
metal ions
moxifloxacin
stability
Chromatographic and densitometric method for determination of moxifloxacin in the presence of products of acidic hydrolysis was developed. The established method had suitable specificity, precision, good accuracy and high sensitivity.In addition, stability of moxifloxacin in acidic solutions at temperature 90°C and 110°C in the presence and absence of metal ions, such as Cu(II), Fe(III), Zn(II), and Al(III) was studied. It was proved that decomposition of moxifloxacin proceeds according to kinetics of the first-order reaction and is dependent on temperature, incubation time and the type of the metal ion. Based on the calculated kinetic (k, t0.1 and t0.5) and thermodynamic (Ea) parameters, it was observed that among studied ions the highest effect on decomposition process of moxifloxacin had Cu(II) ions. The liquid chromatography coupled with mass spectrometry detection (LC-MS) and proton nuclear magnetic resonance (1H NMR) techniques have been used to identify degradation products of moxifloxacin.
dc.abstract.en | Chromatographic and densitometric method for determination of moxifloxacin in the presence of products of acidic hydrolysis was developed. The established method had suitable specificity, precision, good accuracy and high sensitivity.In addition, stability of moxifloxacin in acidic solutions at temperature 90°C and 110°C in the presence and absence of metal ions, such as Cu(II), Fe(III), Zn(II), and Al(III) was studied. It was proved that decomposition of moxifloxacin proceeds according to kinetics of the first-order reaction and is dependent on temperature, incubation time and the type of the metal ion. Based on the calculated kinetic (k, t0.1 and t0.5) and thermodynamic (Ea) parameters, it was observed that among studied ions the highest effect on decomposition process of moxifloxacin had Cu(II) ions. The liquid chromatography coupled with mass spectrometry detection (LC-MS) and proton nuclear magnetic resonance (1H NMR) techniques have been used to identify degradation products of moxifloxacin. | pl |
dc.affiliation | Wydział Farmaceutyczny : Katedra Chemii Organicznej | pl |
dc.affiliation | Wydział Farmaceutyczny : Zakład Toksykologii | pl |
dc.affiliation | Wydział Farmaceutyczny : Zakład Chemii Analitycznej | pl |
dc.contributor.author | Hubicka, Urszula - 129734 | pl |
dc.contributor.author | Żuromska-Witek, Barbara - 200539 | pl |
dc.contributor.author | Krzek, Jan - 130468 | pl |
dc.contributor.author | Walczak, Maria - 133728 | pl |
dc.contributor.author | Żylewski, Marek - 133960 | pl |
dc.date.accession | 2020-07-28 | pl |
dc.date.accessioned | 2020-07-28T06:44:40Z | |
dc.date.available | 2020-07-28T06:44:40Z | |
dc.date.issued | 2012 | pl |
dc.date.openaccess | 0 | |
dc.description.accesstime | w momencie opublikowania | |
dc.description.additional | Bibliogr. s. 830-831 | pl |
dc.description.number | 5 | pl |
dc.description.physical | 821-831 | pl |
dc.description.publication | 0,78 | pl |
dc.description.version | ostateczna wersja wydawcy | |
dc.description.volume | 69 | pl |
dc.identifier.eissn | 2353-5288 | pl |
dc.identifier.issn | 0001-6837 | pl |
dc.identifier.project | ROD UJ / OP | pl |
dc.identifier.uri | https://ruj.uj.edu.pl/xmlui/handle/item/241254 | |
dc.identifier.weblink | https://www.ptfarm.pl/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/14273 | pl |
dc.language | eng | pl |
dc.language.container | eng | pl |
dc.rights | Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa | * |
dc.rights.licence | CC-BY-NC | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/legalcode.pl | * |
dc.share.type | otwarte czasopismo | |
dc.subject.en | fluoroquinolones | pl |
dc.subject.en | 1H NMR | pl |
dc.subject.en | LC-MS | pl |
dc.subject.en | metal ions | pl |
dc.subject.en | moxifloxacin | pl |
dc.subject.en | stability | pl |
dc.subtype | Article | pl |
dc.title | Kinetic and thermodynamic studies of moxifloxacin hydrolysis in the presence and absence of metal ions in acidic solutions | pl |
dc.title.journal | Acta Poloniae Pharmaceutica. Drug Research | pl |
dc.type | JournalArticle | pl |
dspace.entity.type | Publication |
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