Simple view
Full metadata view
Authors
Statistics
AM3 inhibits LPS-induced iNOS expression in mice
nitric oxide
inmunoferon
AM3
anti-inflammatory response
iNOS
We have analyzed the effect of a patented glycoconjugate of natural origin, AM3 (commercially available under the name Inmunoferon) in the expression of iNOS induced by administration of LPS in mice. We have observed that oral treatment with the drug daily for 6 days reduced the levels of expression of iNOS induced by an intravenous pulse of LPS. This effect was significant in the lungs and kidneys, but it was much more marked in the liver. In addition, the levels of nitric oxide in serum were clearly decreased upon treatment with AM3. Together, these results suggest that AM3 modulates the nitric oxide response and points to a possible role for AM3 in the control of the inflammatory response.
| cris.lastimport.wos | 2024-04-09T20:01:41Z | |
| dc.abstract.en | We have analyzed the effect of a patented glycoconjugate of natural origin, AM3 (commercially available under the name Inmunoferon) in the expression of iNOS induced by administration of LPS in mice. We have observed that oral treatment with the drug daily for 6 days reduced the levels of expression of iNOS induced by an intravenous pulse of LPS. This effect was significant in the lungs and kidneys, but it was much more marked in the liver. In addition, the levels of nitric oxide in serum were clearly decreased upon treatment with AM3. Together, these results suggest that AM3 modulates the nitric oxide response and points to a possible role for AM3 in the control of the inflammatory response. | pl |
| dc.affiliation | Wydział Chemii : Zakład Chemii Nieorganicznej | pl |
| dc.contributor.author | Majano, Pedro | pl |
| dc.contributor.author | Alonso-Lebrero, José Luis | pl |
| dc.contributor.author | Kyzioł, Agnieszka - 147927 | pl |
| dc.contributor.author | Martín-Vichez, Samuel | pl |
| dc.contributor.author | Molina-Jiménez, Francisca | pl |
| dc.contributor.author | Brieva, Aurora | pl |
| dc.contributor.author | Pivel, Juan Pablo | pl |
| dc.contributor.author | González, Salvador | pl |
| dc.contributor.author | López-Cabrera, Manuel | pl |
| dc.contributor.author | Moreno-Otero, Ricardo | pl |
| dc.date.accessioned | 2014-12-20T10:59:05Z | |
| dc.date.available | 2014-12-20T10:59:05Z | |
| dc.date.issued | 2005 | pl |
| dc.description.additional | Na publikacji autorka Kyzioł Agnieszka podpisana jako Jańczyk Agnieszka. | pl |
| dc.description.number | 7-8 | pl |
| dc.description.physical | 1165-1170 | pl |
| dc.description.volume | 5 | pl |
| dc.identifier.doi | 10.1016/j.intimp.2005.02.009 | pl |
| dc.identifier.eissn | 1878-1705 | pl |
| dc.identifier.issn | 1567-5769 | pl |
| dc.identifier.uri | http://ruj.uj.edu.pl/xmlui/handle/item/2389 | |
| dc.language | eng | pl |
| dc.language.container | eng | pl |
| dc.rights | Dodaję tylko opis bibliograficzny | * |
| dc.rights.licence | bez licencji | |
| dc.rights.uri | * | |
| dc.subject.en | nitric oxide | pl |
| dc.subject.en | inmunoferon | pl |
| dc.subject.en | AM3 | pl |
| dc.subject.en | anti-inflammatory response | pl |
| dc.subject.en | iNOS | pl |
| dc.subtype | Article | pl |
| dc.title | AM3 inhibits LPS-induced iNOS expression in mice | pl |
| dc.title.journal | International Immunopharmacology | pl |
| dc.type | JournalArticle | pl |
| dspace.entity.type | Publication |