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Combined effects of singlet oxygen and hydroxyl radical in photodynamic therapy with photostable bacteriochlorins : evidence from intracellular fluorescence and increased photodynamic efficacy in vitro
hydroxyl radical
singlet oxygen
bacteriochlorins
phototoxicity
photochemical mechanism
photodynamic therapy
free radicals
ascorbate
Sulfonamides of halogenated bacteriochlorins bearing Cl or F substituents in the
ortho
positions of the phenyl
rings have adequate properties for photodynamic therapy, including strong absorption in the near-infrared
cris.lastimport.wos | 2024-04-09T20:32:35Z | |
dc.abstract.en | Sulfonamides of halogenated bacteriochlorins bearing Cl or F substituents in the ortho positions of the phenyl rings have adequate properties for photodynamic therapy, including strong absorption in the near-infrared $(\lambda_{max}\approx750nm, \varepsilon\approx10^{5}M^{-1}cm^{-1})$, controlled photodecomposition, large cellular uptake, intracellular localization in the endoplasmic reticulum, low cytotoxicity, and high phototoxicity against A549 and S91 cells. The roles of type I and type II photochemical processes are assessed by singlet oxygen luminescence and intracellular hydroxyl radical detection. Phototoxicity of halogenated sulfonamide bacteriochlorins does not correlate with singlet oxygen quantum yields and must be mediated both by electron transfer (superoxide ion, hydroxyl radicals) and by energy transfer (singlet oxygen). The photodynamic efficacy is enhanced when cellular death is induced by both singlet oxygen and hydroxyl radicals. | pl |
dc.affiliation | Wydział Chemii : Zakład Chemii Nieorganicznej | pl |
dc.affiliation | Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki | pl |
dc.contributor.author | Dąbrowski, Janusz - 200579 | pl |
dc.contributor.author | Arnaut, Luis G. | pl |
dc.contributor.author | Pereira, Mariette M. | pl |
dc.contributor.author | Urbańska, Krystyna - 132487 | pl |
dc.contributor.author | Simões, Sérgio | pl |
dc.contributor.author | Stochel, Grażyna - 132108 | pl |
dc.contributor.author | Cortes, Luísa | pl |
dc.date.accessioned | 2015-08-26T08:32:53Z | |
dc.date.available | 2015-08-26T08:32:53Z | |
dc.date.issued | 2012 | pl |
dc.description.number | 7 | pl |
dc.description.physical | 1188-1200 | pl |
dc.description.points | 40 | pl |
dc.description.volume | 52 | pl |
dc.identifier.doi | 10.1016/j.freeradbiomed.2011.12.027 | pl |
dc.identifier.eissn | 1873-4596 | pl |
dc.identifier.issn | 0891-5849 | pl |
dc.identifier.uri | http://ruj.uj.edu.pl/xmlui/handle/item/15033 | |
dc.language | eng | pl |
dc.language.container | eng | pl |
dc.rights | Dodaję tylko opis bibliograficzny | * |
dc.rights.licence | bez licencji | |
dc.rights.uri | * | |
dc.subject.en | hydroxyl radical | pl |
dc.subject.en | singlet oxygen | pl |
dc.subject.en | bacteriochlorins | pl |
dc.subject.en | phototoxicity | pl |
dc.subject.en | photochemical mechanism | pl |
dc.subject.en | photodynamic therapy | pl |
dc.subject.en | free radicals | pl |
dc.subject.en | ascorbate | pl |
dc.subtype | Article | pl |
dc.title | Combined effects of singlet oxygen and hydroxyl radical in photodynamic therapy with photostable bacteriochlorins : evidence from intracellular fluorescence and increased photodynamic efficacy in vitro | pl |
dc.title.journal | Free Radical Biology and Medicine | pl |
dc.type | JournalArticle | pl |
dspace.entity.type | Publication |