W dniach od 2 kwietnia do 5 kwietnia 2024 r. prowadzone będą prace związane z wdrożeniem nowej wersji systemu Repozytorium UJ. Nie będzie możliwe wprowadzanie nowych informacji do repozytorium. Za utrudnienia przepraszamy.
Background. Histidine-rich glycoprotein (HRG) displays anticoagulant and antifibrinolytic properties in animal models, but its
effects in humans are unclear. We investigated serum HRG levels and their associations with the disease stage and prothrombotic
alterations in lung cancer (LC) patients. Methods. In 148 patients with advanced LC prior to anticancer therapy (87
non-small-cell LC and 61 small-cell LC) versus 100 well-matched controls, we measured HRG levels in association with clot
permeability (Ks), clot turbidimetry (lag phase and maximum absorbance), and clot lysis time (CLT). Results. Compared to
controls, LC patients had 45.9% lower HRG levels with no associations with demographics and comorbidities. Decreased HRG,
defined as the 90th percentile of control values (<52.7 μg/ml), was 16 times more common in subjects with than without LC
(OR = 16 4, 95% CI 9.2-23.5, p < 0 01). HRG < 38 μg/ml discriminated stage IIIAB/limited disease from IV/extensive disease (ED)
LC. In LC patients, HRG correlated inversely with CLT (r = −0 41, p < 0 001), but not with other fibrin variables. Among stage
IV/ED LC, HRG correlated significantly with Ks and lag phase (r = 0 28 and r = 0 33, respectively, both p < 0 001). LC patients
with low Ks (10th percentile of control values) combined with prolonged CLT (90th percentile of control values) had reduced
HRG levels compared to the remainder (p = 0 003). No such observations were noted in controls. Conclusions. Our study is the
first to show that decreased HRG levels occur in advanced LC and are associated with the disease stage and hypofibrinolysis.
punktacja wydziałowa:
70
wydział: instytut / zakład / katedra:
Wydział Lekarski : Instytut Kardiologii, Wydział Lekarski : Zakład Patofizjologii