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Prepubertal ultra-low-dose estrogen therapy is associated with healthier lipid profile than conventional estrogen replacement for pubertal induction in adolescent girls with Turner syndrome : preliminary results
Prepubertal ultra-low-dose estrogen therapy is associated with healthier lipid profile than conventional estrogen replacement for pubertal induction in adolescent girls with Turner syndrome : preliminary results
Prepubertal ultra-low-dose estrogen therapy is associated with healthier lipid profile than conventional estrogen replacement for pubertal induction in adolescent girls with Turner syndrome : preliminary results
autor:
Ruszała Anna , Wójcik Małgorzata , Zygmunt-Górska Agata, Januś Dominika , Wojtys Joanna, Starzyk Jerzy
estrogen replacement (LE) therapy in Turner syndrome
(TS) have not been fully investigated to date. The present
study aimed to compare glucose and lipids metabolism
in adolescents with TS on LE and conventional estrogen
replacement (CE).
Methods In 14 TS (mean age 13.8), LE ($17\beta$-estradiol,
62.5 $\mu$g daily) was introduced before age 12 (mean age
10.5), and followed by a pubertal induction regimen after
age 12, and in 14 CE was started after age 12 (mean 14,
SD 1.96). Before, and 3 years after starting $17\beta$-estradiol
growth velocity, bone age, BMI, and selected parameters of
glucose and lipids metabolism were assessed.
Results There were no significant differences between LE
and CE in the mean levels of any parameter before introduction
of $17\beta$-estradiol [total cholesterol (TC): 4.1 vs
4.3 mmol/L, LDL cholesterol (LDLc): 2.2 vs 2.4 mmol/L,
HDL cholesterol (HDLc): 1.6 vs 1.4 mmol/L, triglycerides:
0.9 vs 1.0 mmol/L, fasting glucose: 4.2 vs 4.4 mmol/L,
post-load glucose: 4.8 vs 5.5 mmol/L; fasting insulin: 6.8
vs 8.0 post-load insulin: 21.3 vs 67.0 $\mu$IU/mL, HOMAIR
1.3 vs 1.6]. After three years of treatment, TC and
LDLc levels were significantly lower in LE group (3.8 vs
4.4 mmol/L, p = 0.004; 1.9 vs 2.4 mmol/L, p = 0.03). The
other parameters did not differ significantly. There was no negative impact on growth course and bone age advancement
nor on BMI in LE group.
Conclusion Prepubertal LE is associated with healthier
lipid profile than CE in girls with TS.