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Vascular effects of advanced glycation end-products : content of immunohistochemically detected AGEs in radial artery samples as a predictor for arterial calcification and cardiovascular risk in asymptomatic patients with chronic kidney disease
Vascular effects of advanced glycation end-products : content of immunohistochemically detected AGEs in radial artery samples as a predictor for arterial calcification and cardiovascular risk in asymptomatic patients with chronic kidney disease
Vascular effects of advanced glycation end-products : content of immunohistochemically detected AGEs in radial artery samples as a predictor for arterial calcification and cardiovascular risk in asymptomatic patients with chronic kidney disease
autor:
Krzanowska Katarzyna , Krzanowski Marcin , Gajda Mariusz , Dumnicka Paulina , Jasek-Gajda Ewa , Fedak Danuta , Pietrzycka Agata , Kuźniewski Marek , Litwin Jan , Sułowicz Władysław
Objectives. Our aim was to determine whether vascular deposition of advanced glycation end-products (AGEs) is associated with
arterial calcification and cardiovascular mortality in chronic kidney disease (CKD) patients and to assess the relationships between
vascular content of AGEs and selected clinical and biochemical parameters. Materials and Methods. The study comprised 54 CKD
patients (33 hemodialyzed, 21 predialyzed). Examined parameters included BMI, incidence of diabetes, plasma fasting glucose,
AGEs, soluble receptor for AGEs and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging, serum C-reactive protein (hsCRP),
plasminogen activator inhibitor-1 (PAI-1), and fetuin-A. Fragments of radial artery obtained during creation of hemodialysis access
were stained for calcifications using alizarin red. AGEs deposits were identified immunohistochemically and their relative content
was quantified. Results. Vascular content of AGEs was positively correlated with BMI, hsCRP, fetuin-A, PAI-1, and DPPH scavenging
in simple regression; only fetuin-A was an independent predictor in multiple regression.There was a significant positive trend in the
intensity of AGEs immunostaining among patients with grades 1, 2, and 3 calcifications. AGEs immunostaining intensity predicted
3-year cardiovascular mortality irrespective of patient’s age. Conclusions. The present study demonstrates an involvement of AGEs
in the development of medial arterial calcification and the impact of arterial AGE deposition on cardiovascular mortality in CKD
patients
punktacja wydziałowa:
25
wydział: instytut / zakład / katedra:
Wydział Farmaceutyczny : Zakład Diagnostyki Medycznej, Wydział Farmaceutyczny : Zakład Cytobiologii, Wydział Lekarski : Zakład Histologii, Wydział Lekarski : Zakład Diagnostyki, Wydział Lekarski : Klinika Nefrologii