dc.contributor.author |
Nowak, Natalia |
pl |
dc.contributor.author |
Skupień, Jan [SAP20014478] |
pl |
dc.contributor.author |
Cyganek, Katarzyna [SAP20010227] |
pl |
dc.contributor.author |
Matejko, Bartłomiej [SAP20013948] |
pl |
dc.contributor.author |
Małecki, Maciej [SAP20001383] |
pl |
dc.date.accessioned |
2020-01-17T07:49:49Z |
|
dc.date.available |
2020-01-17T07:49:49Z |
|
dc.date.issued |
2013 |
pl |
dc.identifier.issn |
0012-186X |
pl |
dc.identifier.uri |
https://ruj.uj.edu.pl/xmlui/handle/item/131151 |
|
dc.language |
eng |
pl |
dc.rights |
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne |
* |
dc.rights.uri |
http://creativecommons.org/licenses |
* |
dc.title |
1,5-Anhydroglucitol as a marker of maternal glycaemic control and predictor of neonatal birthweight in pregnancies complicated by type 1 diabetes mellitus |
pl |
dc.type |
JournalArticle |
pl |
dc.description.physical |
709-713 |
pl |
dc.abstract.en |
Aims/hypothesis Most pregnant women with type 1 diabetes
mellitus achieve HbA1c targets; however, macrosomia
remains prevalent and better pregnancy glycaemic markers
are therefore needed. 1,5-Anhydroglucitol (1,5-AG) is a shortterm marker of glycaemia, reflecting a period of 1 to 2 weeks.
Its excretion rate depends on the renal glucose threshold and
thus it is unclear whether it may be used in pregnant type 1
diabetes women. We evaluated 1,5-AG as a glycaemic marker
and birthweight predictor in pregnant women with type 1
diabetes, and compared its performance with HbA1c.
Methods 1,5-AG and HbA1c were measured in 82 pregnant
women with type 1 diabetes. In addition, 58 continuous
glucose monitoring system (CGMS) records were available.
Macrosomia was defined as birthweight >90th centile. The
data were analysed with Pearson’s correlations, and linear
and logistic regression models. Receiver operating characteristic (ROC) analysis was used to evaluate third trimester
1,5-AG as a predictor of macrosomia.
Results Unlike HbA1c, 1,5-AG strongly correlated with
CGMS indices: the AUC above 7.8 mmol/l (r=−0.66; p<
0.001), average maximum glucose (r=−0.58; p<0.001) and
mean glucose (r=−0.54; p<0.001). In the third trimester, 1,5-
AG was the strongest predictor of macrosomia, with ROC
AUC 0.81 (95% CI 0.70, 0.89). In contrast, HbA1c in the third
trimester had a ROC AUC of 0.69 (95% CI 0.58, 0.81). The
best discrimination was achieved when both markers were used
jointly, yielding a ROC AUC of 0.84 (95% CI 0.76, 0.93).
Conclusions/interpretation In pregnant women with type 1
diabetes, 1,5-AG is a better glycaemic marker than HbA1c, as
assessed by CGMS. A decreased third trimester 1,5-AG level,
either singly or with HbA1c, is a strong predictor of macrosomia |
pl |
dc.subject.en |
1,5-Anhydroglucitol |
pl |
dc.subject.en |
birthweight |
pl |
dc.subject.en |
haemoglobin A1c |
pl |
dc.subject.en |
HbA1c |
pl |
dc.subject.en |
pregnancy |
pl |
dc.subject.en |
type 1 diabetes mellitus |
pl |
dc.description.volume |
56 |
pl |
dc.description.number |
4 |
pl |
dc.description.points |
40 |
pl |
dc.identifier.doi |
10.1007/s00125-013-2830-3 |
pl |
dc.identifier.eissn |
1432-0428 |
pl |
dc.title.journal |
Diabetologia |
pl |
dc.language.container |
eng |
pl |
dc.affiliation |
Wydział Lekarski : Klinika Chorób Metabolicznych |
pl |
dc.affiliation |
Wydział Lekarski : Katedra Chorób Metabolicznych |
pl |
dc.subtype |
Article |
pl |
dc.rights.original |
CC-BY-NC; inne; ostateczna wersja wydawcy; w momencie opublikowania; 0 |
pl |
dc.identifier.project |
ROD UJ / OP |
pl |
dc.cm.id |
57751 |
|
dc.cm.date |
2020-01-07 |
|
.pointsMNiSW |
[2013 A]: 40 |
|