Cloud-point extraction (CPE) with RP-HPLC/DAD detection was used to develop a screen for six model basic drugs (paracetamol, promazine, amitriptyline, nortriptyline, clomipramine and chlorpromazine) in human plasma. These drugs’ varied hydrophobicities entail different affinities for the micelle-rich phase and CPE extraction efficiencies. Extraction recovery (except paracetamol) was above 80% and reproducibility (RSD%) ranged from 2.88 to 10.26 intraday and from 3.12 to 12.33 interday. The limits of detection were: 0.125 μg mL -1 (promazine and chlorpromazine), 0.25 μg mL -1 (amitriptyline and nortriptyline) and 0.5 μg mL -1 (paracetamol and clomipramine). The method was linear over the ranges: 0.125 -1.0 μg mL -1 (promazine and chlorpromazine), 0.25-1.0 μg mL -1 (amitriptyline and nortriptyline), 0.5-1.0 μg mL -1 (clomipramine) and 0.5-10 μg mL -1 (paracetamol). The procedure is a good alternative to the SPE or LLE sample preparation usually used.