Disseminated pancreatic neuroendocrine neoplasm (NEN) with an uncommon localisation in the central nervous system : a case report

2017
journal article
article
3
dc.abstract.enBACKGROUND: Neuroendocrine neoplasms (NEN) are rare neoplasms that originate from neuroendocrine cells and are characterized by the potential of hormonal activity. Approximately 70% of these tumours are located in the gastrointestinal system (GI), followed by the bronchi, endocrine glands-like C cells of the thyroid (medullary carcinoma), the parasympathetic and sympathetic system (paragangliomas, pheochromocytoma) and other very rare locations. The prevalence of cerebral metastases in neuroendocrine tumours is estimated by various authors to be approximately 1.5-5%. When the primary tumour is located in the pancreas, it is associated with a risk of cerebral metastases lower than 2%. CASE REPORT: We describe a patient with a disseminated pancreatic NEN that presented with an isolated lesion in the brain. We gathered the important data via medical history,, observation, analysis of medical records, imaging and others diagnostic tests. Despite the fairly rare prevalence of cerebral metastases in NENs, a neurological work-up should be performed. This should include neuroimaging of the brain, preferably with MR, together with the somatostatin receptor scintigraphy (SRS), in each clinically suspicious case. A histopathological examination of the CNS tumour can confirm a dedifferentiation of NEN in the direction of a neuroendocrine carcinoma (NEC - neuroednocrine carcinoma) with a poor prognosis. CONCLUSIONS: Cerebral metastases are diagnosed in 1.5-5% of patients with a neuroendocrine neoplasm. In each case suggestive of a dissemination into the central nervous system, MRI of the brain should be performed.pl
dc.contributor.authorBiałkowska, Joannapl
dc.contributor.authorKolasińska-Ćwikła, Agnieszkapl
dc.contributor.authorMroczkowska, Dorotapl
dc.contributor.authorSowa, Mariuszpl
dc.contributor.authorGrabarczyk, Łukaszpl
dc.contributor.authorMaksymowicz, Wojciechpl
dc.contributor.authorCichocki, Andrzejpl
dc.contributor.authorĆwikła, Jarosław B.pl
dc.date.accessioned2017-04-21T11:14:57Z
dc.date.available2017-04-21T11:14:57Z
dc.date.issued2017pl
dc.date.openaccess0
dc.description.accesstimew momencie opublikowania
dc.description.additionalBibliogr. s. 125pl
dc.description.physical120-125pl
dc.description.versionostateczna wersja wydawcy
dc.description.volume82pl
dc.identifier.doi10.12659/PJR.899007pl
dc.identifier.eissn1899-0967pl
dc.identifier.issn1733-134Xpl
dc.identifier.urihttp://ruj.uj.edu.pl/xmlui/handle/item/39582
dc.languageengpl
dc.language.containerengpl
dc.rightsUdzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska*
dc.rights.licenceCC-BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pl/legalcode*
dc.share.typeotwarte czasopismo
dc.subject.enneoplasm metastasispl
dc.subject.enneuroendocrine tumorspl
dc.subject.enneuroimagingpl
dc.subtypeArticlepl
dc.titleDisseminated pancreatic neuroendocrine neoplasm (NEN) with an uncommon localisation in the central nervous system : a case reportpl
dc.title.journalPolish Journal of Radiologypl
dc.typeJournalArticlepl
dspace.entity.typePublication
dc.abstract.enpl
BACKGROUND: Neuroendocrine neoplasms (NEN) are rare neoplasms that originate from neuroendocrine cells and are characterized by the potential of hormonal activity. Approximately 70% of these tumours are located in the gastrointestinal system (GI), followed by the bronchi, endocrine glands-like C cells of the thyroid (medullary carcinoma), the parasympathetic and sympathetic system (paragangliomas, pheochromocytoma) and other very rare locations. The prevalence of cerebral metastases in neuroendocrine tumours is estimated by various authors to be approximately 1.5-5%. When the primary tumour is located in the pancreas, it is associated with a risk of cerebral metastases lower than 2%. CASE REPORT: We describe a patient with a disseminated pancreatic NEN that presented with an isolated lesion in the brain. We gathered the important data via medical history,, observation, analysis of medical records, imaging and others diagnostic tests. Despite the fairly rare prevalence of cerebral metastases in NENs, a neurological work-up should be performed. This should include neuroimaging of the brain, preferably with MR, together with the somatostatin receptor scintigraphy (SRS), in each clinically suspicious case. A histopathological examination of the CNS tumour can confirm a dedifferentiation of NEN in the direction of a neuroendocrine carcinoma (NEC - neuroednocrine carcinoma) with a poor prognosis. CONCLUSIONS: Cerebral metastases are diagnosed in 1.5-5% of patients with a neuroendocrine neoplasm. In each case suggestive of a dissemination into the central nervous system, MRI of the brain should be performed.
dc.contributor.authorpl
Białkowska, Joanna
dc.contributor.authorpl
Kolasińska-Ćwikła, Agnieszka
dc.contributor.authorpl
Mroczkowska, Dorota
dc.contributor.authorpl
Sowa, Mariusz
dc.contributor.authorpl
Grabarczyk, Łukasz
dc.contributor.authorpl
Maksymowicz, Wojciech
dc.contributor.authorpl
Cichocki, Andrzej
dc.contributor.authorpl
Ćwikła, Jarosław B.
dc.date.accessioned
2017-04-21T11:14:57Z
dc.date.available
2017-04-21T11:14:57Z
dc.date.issuedpl
2017
dc.date.openaccess
0
dc.description.accesstime
w momencie opublikowania
dc.description.additionalpl
Bibliogr. s. 125
dc.description.physicalpl
120-125
dc.description.version
ostateczna wersja wydawcy
dc.description.volumepl
82
dc.identifier.doipl
10.12659/PJR.899007
dc.identifier.eissnpl
1899-0967
dc.identifier.issnpl
1733-134X
dc.identifier.uri
http://ruj.uj.edu.pl/xmlui/handle/item/39582
dc.languagepl
eng
dc.language.containerpl
eng
dc.rights*
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska
dc.rights.licence
CC-BY-NC-ND
dc.rights.uri*
http://creativecommons.org/licenses/by-nc-nd/3.0/pl/legalcode
dc.share.type
otwarte czasopismo
dc.subject.enpl
neoplasm metastasis
dc.subject.enpl
neuroendocrine tumors
dc.subject.enpl
neuroimaging
dc.subtypepl
Article
dc.titlepl
Disseminated pancreatic neuroendocrine neoplasm (NEN) with an uncommon localisation in the central nervous system : a case report
dc.title.journalpl
Polish Journal of Radiology
dc.typepl
JournalArticle
dspace.entity.type
Publication
Affiliations

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