Simple view
Full metadata view
Authors
Statistics
Synaptic plasticity, astrocytes and morphological homeostasis
Recent discoveries suggest that astrocytes are an integral part of synaptic connections, as they sense and modulate synaptic activity. Moreover, there is evidence that astrocytes change the number of synaptic connections directly via synaptogenic signals or indirectly, by modifying the morphology of axons and dendrites. Here, we formulate the hypothesis that astrocytes mediate the morphological homeostasis of nerve cells, which is any adaptation of the morphology of a neuron to preserve its ability to respond to and generate synaptic activity during learning and mernory-induced changes. We argue that astrocytes control neuronal morphology locally and across long-ranging assemblies of neurons and that on the other hand, astrocytes, are part of the engram with plasticity-related changes affecting their morphology.
cris.lastimport.scopus | 2024-04-07T13:02:43Z | |
dc.abstract.other | Recent discoveries suggest that astrocytes are an integral part of synaptic connections, as they sense and modulate synaptic activity. Moreover, there is evidence that astrocytes change the number of synaptic connections directly via synaptogenic signals or indirectly, by modifying the morphology of axons and dendrites. Here, we formulate the hypothesis that astrocytes mediate the morphological homeostasis of nerve cells, which is any adaptation of the morphology of a neuron to preserve its ability to respond to and generate synaptic activity during learning and mernory-induced changes. We argue that astrocytes control neuronal morphology locally and across long-ranging assemblies of neurons and that on the other hand, astrocytes, are part of the engram with plasticity-related changes affecting their morphology. | pl |
dc.affiliation | Wydział Biologii i Nauk o Ziemi : Instytut Zoologii | pl |
dc.contributor.author | Ślęzak, Michał - 143670 | pl |
dc.contributor.author | Pfrieger, Frank W. | pl |
dc.contributor.author | Sołtys, Zbigniew - 147734 | pl |
dc.date.accessioned | 2016-09-28T10:47:48Z | |
dc.date.available | 2016-09-28T10:47:48Z | |
dc.date.issued | 2006 | pl |
dc.description.number | 2-3 | pl |
dc.description.physical | 84-91 | pl |
dc.description.volume | 99 | pl |
dc.identifier.doi | 10.1016/j.jphysparis.2005.12.082 | pl |
dc.identifier.eissn | 1769-7115 | pl |
dc.identifier.issn | 0928-4257 | pl |
dc.identifier.uri | http://ruj.uj.edu.pl/xmlui/handle/item/30922 | |
dc.language | eng | pl |
dc.language.container | eng | pl |
dc.rights.licence | bez licencji | |
dc.subtype | Article | pl |
dc.title | Synaptic plasticity, astrocytes and morphological homeostasis | pl |
dc.title.journal | Journal of Physiology. Paris | pl |
dc.title.volume | The World of the Synapse : Molecular Basis, Pathologies and Drug Discovery | pl |
dc.type | JournalArticle | pl |
dspace.entity.type | Publication |