tytuł:
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Carboxylated and intact osteocalcin predict adiponectin concentration in hemodialyzed patients |
autor: |
Kuźniewski Marek , Fedak Danuta , Dumnicka Paulina , Kapusta Maria , Stępień Ewa , Chowaniec Eve, Krzanowska Katarzyna , Krzanowski Marcin , Chmiel Grzegorz, Solnica Bogdan , Sułowicz Władysław
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tytuł czasopisma:
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Renal Failure |
tom: |
38 |
numer:
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3 |
data wydania
:
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2016 |
strony:
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451-457 |
ISSN: |
0886-022X
|
eISSN: |
1525-6049
|
DOI: |
10.3109/0886022X.2016.1138830
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język: |
angielski |
język czasopisma:
|
angielski |
abstrakt w j. angielskim: |
Purpose Disrupted bone metabolism in patients with chronic kidney disease (CKD) is associated with elevated concentrations of biochemical bone markers. Recently, animal studies show the role of osteocalcin in energy metabolism, which is partially confirmed in humans. The aim of our study was to evaluate the relationships between serum concentrations of bone markers and indices of energy metabolism in CKD patients on maintenance hemodialysis; in particular, the relationship between various forms of osteocalcin and adiponectin. Patients and methods The cross-sectional study included 155 hemodialyzed stage 5 CKD patients. Serum concentrations of glucose, insulin, adiponectin, bone alkaline phosphatase (bALP), tartrate resistant acid phosphatase (TRAP), carboxylated (cOC), undercarboxylated (ucOC), and intact osteocalcin (OC) were determined. Results In total cohort, bALP, TRAP, cOC, and ucOC negatively correlated with BMI. All analyzed bone markers positively correlated with adiponectin in total cohort and in men. In multiple linear regression analysis including all patients, log(cOC) and log(intact OC) were the only bone markers that predicted log(adiponectin) (beta = 0.22; p = 0.016 and beta = 0.26; p = 0.010) independently of sex, dialysis vintage, CRP, insulin, iPTH concentrations, BMI, and age. Conclusions Our data confirm the positive association between cOC, intact OC, and adiponectin concentrations in CKD patients on maintenance hemodialysis. |
słowa kluczowe w j. angielskim: |
adiponectin, tartrate resistant acid phosphatase, end stage renal disease, bone alkaline phosphatase, osteocalcin |
wydział: instytut / zakład / katedra: |
Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego, Wydział Lekarski : Klinika Nefrologii, Wydział Lekarski : Zakład Diagnostyki, Wydział Farmaceutyczny : Zakład Diagnostyki Medycznej |
typ: |
artykuł w czasopiśmie |
podtyp: |
artykuł |
punktacja MEiN [2016 A]: 15