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Orientation of lutein in a lipid bilayer : revisited
molecular modeling
tilt angle
macular pigment
Lutein is present in the human retina and lens, where it plays a protective role. As lutein is associated with the lipid matrix of biomembranes, the role depends on its membrane location. Experimental studies predicted two orientations of lutein in a phosphatidylcholine (PC) bi-layer: vertical and horizontal. Using a molecular dynamics simulation, we observed, in two different PC bilayers, both orientations of lutein, and in each bilayer, a single change from vertical to horizontal orientation or vice ver-sa. Both orientations were stabilized by hydrogen bonding of lutein OH groups with mainly carbonyl but also phosphate oxygen atoms of PC.
dc.abstract.en | Lutein is present in the human retina and lens, where it plays a protective role. As lutein is associated with the lipid matrix of biomembranes, the role depends on its membrane location. Experimental studies predicted two orientations of lutein in a phosphatidylcholine (PC) bi-layer: vertical and horizontal. Using a molecular dynamics simulation, we observed, in two different PC bilayers, both orientations of lutein, and in each bilayer, a single change from vertical to horizontal orientation or vice ver-sa. Both orientations were stabilized by hydrogen bonding of lutein OH groups with mainly carbonyl but also phosphate oxygen atoms of PC. | pl |
dc.affiliation | Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki Obliczeniowej i Bioinformatyki | pl |
dc.contributor.author | Pasenkiewicz-Gierula, Marta - 131288 | pl |
dc.contributor.author | Baczyński, Krzysztof - 135790 | pl |
dc.contributor.author | Murzyn, Krzysztof - 130817 | pl |
dc.contributor.author | Markiewicz, Michał - 160663 | pl |
dc.date.accession | 2019-02-26 | pl |
dc.date.accessioned | 2016-05-19T06:08:51Z | |
dc.date.available | 2016-05-19T06:08:51Z | |
dc.date.issued | 2012 | pl |
dc.date.openaccess | 0 | |
dc.description.accesstime | w momencie opublikowania | |
dc.description.number | 1 | pl |
dc.description.physical | 115-118 | pl |
dc.description.version | ostateczna wersja wydawcy | |
dc.description.volume | 59 | pl |
dc.identifier.eissn | 1734-154X | pl |
dc.identifier.issn | 0001-527X | pl |
dc.identifier.project | ROD UJ / P | pl |
dc.identifier.uri | http://ruj.uj.edu.pl/xmlui/handle/item/26449 | |
dc.identifier.weblink | http://www.actabp.pl/pdf/1_2012/115.pdf | pl |
dc.identifier.weblink | https://ojs.ptbioch.edu.pl/index.php/abp/article/view/2184 | pl |
dc.language | eng | pl |
dc.language.container | eng | pl |
dc.rights | Udzielam licencji. Uznanie autorstwa - Na tych samych warunkach 4.0 Międzynarodowa | * |
dc.rights.licence | CC-BY-SA | |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/legalcode.pl | * |
dc.share.type | otwarte czasopismo | |
dc.subject.en | molecular modeling | pl |
dc.subject.en | tilt angle | pl |
dc.subject.en | macular pigment | pl |
dc.subtype | Article | pl |
dc.title | Orientation of lutein in a lipid bilayer : revisited | pl |
dc.title.journal | Acta Biochimica Polonica | pl |
dc.type | JournalArticle | pl |
dspace.entity.type | Publication |
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