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Analysis of DNA mismatch repair gene expression and mutations in thyroid tumours
thyroid cancer
MLH1
MSH2
PMS1
PMS2
DNA mismatch repair
Alterations of DNA mismatch repair genes, primarily demonstrated in hereditary nonpolyposis colorectal carcinomas, were reported to be of relevance for the progression of several sporadic tumours. In this study, the expression and mutations of MLH1, MSH2, PMS1 and PMS2 in a panel of thyroid tumours, including nodular hyperplasia, follicular adenomas and carcinomas, were investigated. The expressions of MLH1, MSH2 and PMS1 were generally higher in malignant tumours than in benign lesions (p<0.01). This observation can find potential diagnostic application in the differentiation of follicular adenomas from follicullar carcinomas of the thyroid. No point mutations in the DNA mismatch repair genes MSH2 (exon 12, 13) and MLH1 (exon 15, 16) were found.
dc.abstract.en | Alterations of DNA mismatch repair genes, primarily demonstrated in hereditary nonpolyposis colorectal carcinomas, were reported to be of relevance for the progression of several sporadic tumours. In this study, the expression and mutations of MLH1, MSH2, PMS1 and PMS2 in a panel of thyroid tumours, including nodular hyperplasia, follicular adenomas and carcinomas, were investigated. The expressions of MLH1, MSH2 and PMS1 were generally higher in malignant tumours than in benign lesions (p<0.01). This observation can find potential diagnostic application in the differentiation of follicular adenomas from follicullar carcinomas of the thyroid. No point mutations in the DNA mismatch repair genes MSH2 (exon 12, 13) and MLH1 (exon 15, 16) were found. | pl |
dc.affiliation | Wydział Lekarski | pl |
dc.contributor.author | Ruschenburg, Ilka | pl |
dc.contributor.author | Vollheim, Beate | pl |
dc.contributor.author | Stachura, Jerzy | pl |
dc.contributor.author | Cordon-Cardo, Carlos | pl |
dc.contributor.author | Korabiowska, Monika | pl |
dc.date.accession | 2020-10-19 | pl |
dc.date.accessioned | 2020-10-19T08:33:01Z | |
dc.date.available | 2020-10-19T08:33:01Z | |
dc.date.issued | 2006 | pl |
dc.date.openaccess | 24 | |
dc.description.accesstime | po opublikowaniu | |
dc.description.additional | Bibliogr. s. 2111-2112 | pl |
dc.description.number | 3A | pl |
dc.description.physical | 2107-2112 | pl |
dc.description.publication | 0,57 | pl |
dc.description.version | ostateczna wersja wydawcy | |
dc.description.volume | 26 | pl |
dc.identifier.eissn | 1791-7530 | pl |
dc.identifier.issn | 0250-7005 | pl |
dc.identifier.project | ROD UJ / OP | pl |
dc.identifier.uri | https://ruj.uj.edu.pl/xmlui/handle/item/248297 | |
dc.identifier.weblink | http://ar.iiarjournals.org/content/26/3A/2107.full.pdf+html | pl |
dc.language | eng | pl |
dc.language.container | eng | pl |
dc.rights | Dozwolony użytek utworów chronionych | * |
dc.rights.licence | OTHER | |
dc.rights.uri | http://ruj.uj.edu.pl/4dspace/License/copyright/licencja_copyright.pdf | * |
dc.share.type | otwarte czasopismo | |
dc.subject.en | thyroid cancer | pl |
dc.subject.en | MLH1 | pl |
dc.subject.en | MSH2 | pl |
dc.subject.en | PMS1 | pl |
dc.subject.en | PMS2 | pl |
dc.subject.en | DNA mismatch repair | pl |
dc.subtype | Article | pl |
dc.title | Analysis of DNA mismatch repair gene expression and mutations in thyroid tumours | pl |
dc.title.journal | Anticancer Research | pl |
dc.type | JournalArticle | pl |
dspace.entity.type | Publication |
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