The escalation of the contagion effect results in many consequences in various spheres of life. The important problem, which looks for further discussion is the impact of centralization and self-learning on the ability to response to contagion effect escalation. The system approach methodology seems to be the most appropriate one to resolve such complex issues. For this reason, a procedure of identification of system amidst contagion was developed. Consequently, it was applied to interpret the multinationals response amidst contagion. The authors suggest that each branch can build its own model of prevention against contagion within the decentralized system. Additionally, it should be based on mechanism of self-similarity and redundancy.